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Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae--a review.
TLDR
This review aims to systematically summarize and analyze the anti-cancer properties of terpenoids, the main components of essential oils in Rhizoma Curcumae, and thus enable the development of new anti- cancer drugs. Expand
Terpenoids: natural products for cancer therapy
TLDR
The anti-cancer activity of terpenoids appears promising and will potentially open more opportunities for cancer therapy, however, current studies are restricted to descriptive findings and lack mechanistic insights and systematic structure–activity relationship (SAR) studies. Expand
Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species
TLDR
DHA inhibited the proliferation of a panel of tumor cells originated from different tissue types and uncovered that DHA induces apoptosis is dependent of iron and p38 MAPK activation but not ROS in HL-60 cells. Expand
Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
TLDR
The present study summarizes the achievements of the 50 years of research on cucurbitacins and systematically analyze their bioactivities with an emphasis on their anticancer effects. Expand
Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum – a review
TLDR
This review aims to summarize and analyze the current knowledge on the anti-cancer properties and mechanisms of G. lucidum triterpenoids (GLTs) and discuss the future prospects of the application of GLTs in cancer treatment. Expand
Osimertinib resistance in non-small cell lung cancer: Mechanisms and therapeutic strategies.
TLDR
The resistance mechanisms and therapeutic strategies for OSI-resistant NSCLC were summarized to direct further use of OSI and aid in the development of novel drugs or strategies to overcome OSI resistance. Expand
Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells.
TLDR
It is shown that TDT-induced apoptosis and protective autophagy in 95D cells mediated by increasing intracellular ROS production. Expand
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.
TLDR
It is suggested that c-myC may potentially be a biomarker candidate for prediction of the antitumor efficacies of ARTs and might be useful in the treatment of c-MYC-overexpressing tumors. Expand
The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
TLDR
A systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones is provided, aiming to bring new insights for further research and development of this ancient herb. Expand
Cytosolic calcium mediates RIP1/RIP3 complex‐dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells
TLDR
It is demonstrated that RIP1/RIP3 complex‐triggered cytosolic calcium accumulation is a critical mediator in MAM‐induced necroptosis through sustained JNK activation and mitochondrial ROS production. Expand
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