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Lensless microfluidic imaging with super-resolution processing has become a promising solution to miniaturize the conventional flow cytometer for point-of-care applications. The previous multi-frame super-resolution processing system can improve resolution but has limited cell flow rate and hence low throughput when capturing multiple subpixel-shifted cell(More)
Surface Acoustic Wave (SAW) has emerged as a powerful technique for kinds of application, such as gas sensor, on-chip manipulation of microparticles or biological cells. In this paper, we present a numerical simulation and experimental study of standing surface acoustic wave (SSAW) induced acoustophoresis to assemble the particle samples in a microchannel.(More)
Conventional Coulter counters have been introduced as an important tool in biological cell assays since several decades ago. Recently, the emerging portable Coulter counter has demonstrated its merits in point of care diagnostics, such as on chip detection and enumeration of circulating tumor cells (CTC). The working principle is based on the cell(More)
Portable devices have been introduced to provide companion diagnostics in many applications such as personalized healthcare monitoring since several decades ago. Recently the polydimethylsiloxane (PDMS)-based microfluidic chip enables a cost effective platform for point of care diagnostics. In this paper, we present a systematic theoretical and experimental(More)
On-chip flow cytometry provides a powerful tool to characterize cell samples for point-of-care diagnosis. In particular, sample focusing at specific locations along the microchannel is crucial to ensure the accuracy of detection. In this paper, we present a simple strategy of interfacing an RF-activated standing surface acoustic wave (SSAW) substrate with a(More)
A silicon-nanowire-based Coulter counter has been designed and fabricated for particle/cell enumeration. The silicon nanowire was fabricated in a fully complementary metal-oxide-semiconductor (CMOS)-compatible process and used as a field effect transistor (FET) device. The Coulter counter device worked on the principle of potential change detection(More)
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