Learn More
In an effort to examine liver injury, immune response, and other physiological effects in mice caused by intragastric administration of nanoparticulate anatase titanium dioxide (5nm), we assessed T lymphocytes, B lymphocyte and NK lymphocyte counts, hematological indices, biochemical parameters of liver functions, and histopathological changes in(More)
Previous research on the biological and toxic effects of nano-TiO(2) particles on animals only limit to a single dose. However, the toxicity caused by single dose nano-TiO(2) does not truly represent ecological and health effects of nano-TiO(2) retained in the environment. In order to further evaluate the toxicity of nano-TiO(2) particles, nano-anatase(More)
Although it is known that nano-TiO2or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO2(5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated. The results showed the(More)
A three-class support vector classification (SVC) model with high prediction accuracy for the training, test and overall data sets (95.2%, 88.6% and 93.1%, respectively) was developed based on the molecular descriptors of 148 Akt/protein kinase B (PKB) inhibitors. Then, support vector regression (SVR) method was applied to set up a more accurate model with(More)
Support vector machine (SVM) was applied to predict vasorelaxation effect of different structural molecules. A good classification model had been established, and the accuracy in prediction for the training, test, and overall datasets was 93.0%, 82.6%, and 89.5%, respectively. Furthermore, the model was used to predict the activity of a series of prenylated(More)
A series of flavonoid derivatives were designed, synthesized. Their vasorelaxant activities were evaluated experimentally against rat aorta rings pretreated with phenylephrine (PE). Among them, 6-hydroxy-8-allyl-4'-chloro-flavanone 8q exhibited the highest vasodilatory activity (EC(50)=4.6 microM, E(max)=95.1%). The 3D-QSAR analysis was carried out by(More)
In this paper, we focus on the optimization of the Rete algorithm on aspects of memory consumption and time-consuming in matching process. Facing the problem of requirement of limited memory and quick response from users in the rule pattern matching process of dynamic evolution of software system,on the basis of the classic Rete algorithm and from the(More)
The design and optimization of p53-MDM2 interaction inhibitors has attracted a great deal of interest in the development of new anticancer agents. Systematical 2D-QSAR studies on 98 isoindolinone-based p53-MDM2 interaction inhibitors were carried out using linear and the non-linear mathematical methods. At first, a forward stepwise-multiple linear(More)
Pharmacophore models of cyclin-dependent kinase-1 (CDK1) inhibitors were established by using the Catalyst/HypoGen. The best pharmacophore model, Hypo1, consists of one hydrogen bond acceptor (HBA), one hydrogen bond donor (HBD), one hydrophobic (HY) and one ring aromatic (RA) feature. The validation results of Hypo1 through cost analysis, test set(More)
  • 1