Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis
The findings that miR-146a overexpression suppresses T cell apoptosis indicate a role of miR -146a in RA pathogenesis and provide potential novel therapeutic targets.
Expression of B7-H1 in Inflammatory Renal Tubular Epithelial Cells
- Yongwen Chen, Jingbo Zhang, Yuzhang Wu
- Biology, MedicineNephron Experimental Nephrology
- 11 November 2005
B7-H1 is an inducible renal tubular epithelial antigen that inhibits T cell activation and active delivery of the B7- H1 inhibitory signal represents a novel therapeutic strategy in autoimmune renal diseases.
Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
- K. Ma, Jingyi Li, Yongfei Fang, Liwei Lu
- BiologyInternational Journal of Molecular Sciences
- 1 June 2015
R roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients and mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.
Renal tubular epithelial expression of the coinhibitory molecule B7-DC (programmed death-1 ligand).
- Jingbo Zhang, Yongwen Chen, Yuzhang Wu
- Biology, MedicineJN. Journal of Nephrology (Milano. )
- 1 July 2006
It is speculated that B7-DC might play an important role in maintaining peripheral tolerance, and in protecting the epithelium from immune-mediated tubulointerstitial injury.
The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells
- L. Zou, Jingran Zhou, Yuzhang Wu
- Biology, ChemistryProceedings of the National Academy of Sciences
- 15 September 2009
Examination of siRNA-mediated knockdown of 57 Rab GTPases shows that Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross- presentation.
Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells.
Results indicate that miR-146a may be involved in the pathogenesis of ALPS by targeting Fas and may therefore serve as a novel therapeutic target.
Triptolide inhibits B7-H1 expression on proinflammatory factor activated renal tubular epithelial cells by decreasing NF-kappaB transcription.
Mutual activation of CD4+ T cells and monocytes mediated by NKG2D-MIC interaction requires IFN-gamma production in systemic lupus erythematosus.
The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis
Serious data suggest that serum levels of LL37 and IFN-α may reflect both local renal inflammation and systemic inflammation in AAV patients, particularly those with crescentic formation.