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Epigallocatechin-3-gallate (EGCG) repressed the invasion of lung carcinoma 95-D cells in invasion assay. RT-PCR analysis illuminated that 40 microM EGCG down-regulated the expression of MMP-9 by 45.7% and the result of Western blot analysis provided further evidence. NF-kappa B localized in the nucleus of the 95-D cells was diminished in a dose-dependent(More)
Expelling heterologous compounds out of hosts by transporters is a potential strategy to enhance product titers in microbial cell factories. In this work, to increase heterologous polyketide 6-deoxyerythronolide B (6dEB, erythromycin precursor) production, tripartite multidrug efflux pumps MacAB-TolC, AcrAB-TolC, MdtEF-TolC, and MexAB-OprM were modulated in(More)
BACKGROUND To solve the efficiency versus cytotoxicity and tumor-targeting problems of polyethylenimine (PEI) used as a nonviral gene delivery vector, a degradable PEI derivate coupled to a bifunctional peptide R13 was developed. METHODS First, we synthesized a degradable PEI derivate by crosslinking low-molecular-weight PEI with pluronic P123, then used(More)
The validity of the maximum capacity criterion applied to realize high-rank line-of-sight (LoS) multiple-input multiple-output (MIMO) channels was investigated for high speed railway scenarios in this paper. Performance is evaluated with respect to ergodic capacity. Numerical results demonstrate that by simply adjusting antenna spacing as a function of the(More)
Collagen is a family of fibrous proteins present in skin, bone, tendon, teeth, cartilage of multicellular organisms. Collagen and its hydrolysate were prepared from squid skin hydrolyzed with proteases. The collagen hydrolysate obtained could remarkably extend the lifespan of fruit fly Drosophila Melanogaster. The maximum lifespan fruit flies increased from(More)
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