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Internet of Things (IoT) is playing a more and more important role after its showing up, it covers from traditional equipment to general household objects such as WSNs and RFID. With the great potential of IoT, there come all kinds of challenges. This paper focuses on the security problems among all other challenges. As IoT is built on the basis of the(More)
In nanometer-scale VLSI physical design, clock network becomes a major concern on determining the total performance of digital circuit. Clock skew and PVT (Process, Voltage and Temperature) variations contribute a lot to its behavior. Previous works mainly focused on skew and wirelength minimization. It may lead to negative influence towards these process(More)
ePlace is a generalized analytic algorithm to handle large-scale standard-cell and mixed-size placement. We use a novel density function based on electrostatics to remove overlap and Nesterov's method to minimize the nonlinear cost. Steplength is estimated as the inverse of Lipschitz constant, which is determined by our dynamic prediction and backtracking(More)
Routability optimization has become a major concern in physical design of VLSI circuits. Due to the recent advances in VLSI technology, interconnect has become a dominant factor of the overall performance of a circuit. In order to optimize interconnect cost, we need a good congestion estimation method to predict routability in the early designing stages.(More)
BACKGROUND Osteoporosis is a bone disorder associated with loss of bone mineral density and micro architecture. A balance of osteoblasts and osteoclasts activities maintains bone homeostasis. Increased bone loss due to increased osteoclast and decreased osteoblast activities is considered as an underlying cause of osteoporosis. METHODS AND FINDINGS The(More)
Clock tree synthesis plays an important role on the total performance of chip. Gated clock tree is an effective approach to reduce the dynamic power usage. In this paper, two novel gated clock tree synthesizers, power-aware clock tree synthesizer (PACTS) and powerand slew-aware clock tree synthesizer (PSACTS), are proposed with zero skew achieved based on(More)
Despite recent advances in cardiovascular medicine, ischemic heart disease remains the major cause of death in the United States and abroad. Cell-based therapy for degenerative diseases like myocardial ischemia using stem cells is currently under serious investigation. Various types of stem cells are being considered to be candidates for cell(More)
Hematopoietic stem cell transplantation has been applied as a standard procedure of treatment for hematological disorders like multiple myeloma and leukemia for several decades. Various sources of stem cells like bone marrow, peripheral blood and umbilical cord blood are used for the transplantation. Among these umbilical cord blood is currently preferred(More)
BACKGROUND Mechanisms of human Vγ2Vδ2 T cell-mediated tumor immunity have yet to be fully elucidated. METHODS AND FINDINGS At least some tumor cell recognition is mediated by NKG2D-MICA interactions. Herein, by using MTT assay and PI-BrdU co-staining and Western-blot, we show that these Vγ2Vδ2 T cells can limit the proliferation of ovarian tumor cells by(More)
Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies in(More)