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Internet of Things (IoT) is playing a more and more important role after its showing up, it covers from traditional equipment to general household objects such as WSNs and RFID. With the great potential of IoT, there come all kinds of challenges. This paper focuses on the security problems among all other challenges. As IoT is built on the basis of the(More)
—Clock tree synthesis plays an important role on the total performance of chip. Gated clock tree is an effective approach to reduce the dynamic power usage. In this paper, two novel gated clock tree synthesizers, power-aware clock tree synthesizer (PACTS) and power-and slew-aware clock tree synthesizer (PSACTS), are proposed with zero skew achieved based on(More)
Many ovarian cancer cells express stress-related molecule MICA/B on their surface that is recognized by Vγ2Vδ2 T cells through their NKG2D receptor, which is transmitted to downstream stress-signaling pathway. However, it is yet to be established how Vγ2Vδ2 T cell-mediated recognition of MICA/B signal is transmitted to downstream stress-related molecules.(More)
Hematopoietic stem cell transplantation has been applied as a standard procedure of treatment for hematological disorders like multiple myeloma and leukemia for several decades. Various sources of stem cells like bone marrow, peripheral blood and umbilical cord blood are used for the transplantation. Among these umbilical cord blood is currently preferred(More)
In nanometer-scale VLSI physical design, clock network becomes a major concern on determining the total performance of digital circuit. Clock skew and PVT (Process, Voltage and Temperature) variations contribute a lot to its behavior. Previous works mainly focused on skew and wirelength minimization. It may lead to negative influence towards these process(More)
Routability optimization has become a major concern in physical design of VLSI circuits. Due to the recent advances in VLSI technology, interconnect has become a dominant factor of the overall performance of a circuit. In order to optimize interconnect cost, we need a good congestion estimation method to predict routability in the early designing stages.(More)
—Global routing remains a fundamental physical design problem. We observe that large circuits cause high memory cost 1 , and modern routers could not optimize the routing path of each two-pin subnet. In this paper, (1) we develop a dynamic topology update technique to improve routing quality (2) we improve the memory efficiency with negligible performance(More)
BACKGROUND Mechanisms of human Vγ2Vδ2 T cell-mediated tumor immunity have yet to be fully elucidated. METHODS AND FINDINGS At least some tumor cell recognition is mediated by NKG2D-MICA interactions. Herein, by using MTT assay and PI-BrdU co-staining and Western-blot, we show that these Vγ2Vδ2 T cells can limit the proliferation of ovarian tumor cells by(More)
Molecular-focused cancer therapies, e.g., molecularly targeted therapy and immunotherapy, so far demonstrate only limited efficacy in cancer patients. We hypothesize that underestimating the role of biophysical factors that impact the delivery of drugs or cytotoxic cells to the target sites (for associated preferential cytotoxicity or cell signaling(More)
ePlace is a generalized analytic algorithm to handle large-scale standard-cell and mixed-size placement. We use a novel density function based on electrostatics to remove overlap and Nesterov's method to minimize the nonlinear cost. Steplength is estimated as the inverse of Lipschitz constant, which is determined by our dynamic prediction and backtracking(More)