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Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1
TLDR
Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-α, p53, and HMGB1, and matrine may have had a therapeutic effect on CRC via inhibition of HMGB 1 signaling, and this occurred through downregulation of IL/TNF/α, andHMGB1. Expand
Diabetes mellitus and hepatocellular carcinoma: comparison of Chinese patients with and without HBV-related cirrhosis.
TLDR
DM was found to be the sole independent factor associated with HCC in patients with HBV-related cirrhosis, compared with those without cirrhotic disease, after other known concomitant diseases were excluded. Expand
Safety and efficacy of total parenteral nutrition versus total enteral nutrition for patients with severe acute pancreatitis: a meta-analysis
TLDR
This meta-analysis indicates that TEN is safer and more effective than TPN for patients with SAP, and when both TEN and TPN have a role in the management of SAP, T EN is the preferred option. Expand
Potential role of diabetes mellitus in the progression of cirrhosis to hepatocellular carcinoma: a cross-sectional case-control study from Chinese patients with HBV infection.
TLDR
DM is an independent factor in the progression of cirrhosis to HCC, but the role may be contrary to the current viewpoint. Expand
Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver.
TLDR
The genetic polymorphism of CYPIIE1 on the position of Pst I and Rsa I is related to the susceptibility of fatty liver, and C2 gene may play a key role in the pathogenesis of fatty Liver. Expand
Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing.
TLDR
Compared with colonic intraepithelial neoplasia, differentially expressed lncRNAs in early-stage COAD were obtained by RNA-sequencing and DEmiRNA-DElnc RNA-DEmRNA interaction analysis and functional annotation were performed. Expand
Significance and prognostic value of increased serum direct bilirubin level for lymph node metastasis in Chinese rectal cancer patients.
TLDR
Higher serum direct bilirubin concentration was associated with the increased risk of LNM and poor prognosis in the rectal cancers in Chinese rectal cancer patients. Expand
The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases
TLDR
Evidence linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development is presented to identify future effective approaches based on the gut microbiota for preventing autoimmune diseases. Expand
Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population
TLDR
Current evidence suggests that the rs2735383C/G polymorphism in the 3’-untranslated region of NBS1 might contribute to the risk for colorectal cancer. Expand
Pre-operative predictive factors for intra-operative pathological lymph node metastasis in rectal cancers.
TLDR
Age, abdominal pain or discomfort, allergic history and direct bilirubin were associated with pLNM, which may be helpful for preoperative selection and found to be associated with prognosis. Expand
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