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BACKGROUND Endostar™ (rh-endostatin, YH-16) is a new recombinant human endostatin developed by Medgenn Bioengineering Co. Ltd., Yantai, Shandong, P.R.China. Pre-clinical study indicated that YH-16 could inhibit tumor endothelial cell proliferation, angiogenesis and tumor growth. Phase I and phase II studies revealed that YH-16 was effective as single agent(More)
Signature-based network intrusion-detection systems (NIDSs) often report a massive number of simple alerts of low-level security-related events. Many of these alerts are logically involved in a single multi-stage intrusion incident and a security officer often wants to analyze the complete incident instead of each individual simple alert. This paper(More)
Adeno-associated virus (AAV) empty capsids typically co-purify with genome containing AAV2 vectors purified by column chromatography. This study describes a method to remove empty capsids from genome containing vector particles by anion exchange chromatography. The separation is based on the slightly less anionic character of empty particles compared to(More)
We propose a method to verify the result of attacks detected by signature-based network intrusion detection systems using lightweight protocol analysis. The observation is that network protocols often have short meaningful status codes saved at the beginning of server responses upon client requests. A successful intrusion that alters the behavior of a(More)
Incomplete or improper input validation is one of the major sources of security bugs in programs. While traditional approaches often focus on detecting string related buffer overflow vulnerabilities, we present an approach to automatically detect potential integer misuse, such as integer overflows in C programs. Our tool is based on CQual, a static analysis(More)
BACKGROUND The effect of ACE inhibitors on the prognosis of chronic heart failure patients with preserved left ventricular ejection fraction remains controversial. AIMS To assess the impact of ACE inhibitors on the prognosis of chronic heart failure patients with preserved left ventricular ejection fraction. METHODS AND RESULTS Seven prospective studies(More)
BACKGROUND Relationship of left ventricular diastolic dysfunction (LVDD) with parameters that could provide more information than hemodynamic renal indexes has not been clarified. We aimed to explore the association of comprehensive renal parameters with LVDD in a community-based elderly population. METHODS 1,166 community residents (aged ≥ 65 years, 694(More)
Coronary tortuosity (CT) would alter the local wall shear stress (WSS) and may become a risk factor for atherosclerosis. Here we performed a systematic computational study to relate CT morphological parameters to abnormal WSS, which is a predisposing factor to the formation of atherosclerotic lesions. Several idealized left coronary artery (LCA) models were(More)
AIMS Chronic heart failure with normal left ventricular ejection fraction (HFNEF) is not only common, but also carries a high risk of substantial morbidity and mortality. However, few studies have been conducted in this population and no proven treatment is available. Although beta-blockers are evidence-based first-line therapy in systolic heart failure,(More)
Adiponectin is reported to relate with cardiovascular diseases, we sought to examine whether adiponectin is associated with disease progression of heart failure from hypertension in rats in comparison with other known biomarkers and echocardiographic parameters. Spontaneously hypertensive rats (SHR, n = 35), aged 1 month, were used and followed up to 18(More)