Jingkai Li

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Multidrug resistance protein Pdr5p is a yeast ATP-binding cassette (ABC) transporter in the plasma membrane. It confers multidrug resistance by active efflux of intracellular drugs. However, the highly polymorphic Pdr5p from clinical strain YJM789 loses its ability to expel azole and cyclohexmide. To investigate the role of amino acid changes in this(More)
In this paper, we propose a new measure of semantic similarity based on multi-prototype concepts. Our proposed concept seman­ tic similarity is based on the prototype view in cognitive psychol­ ogy, and it can measure the semantic similarity between two con­ cepts in a way which is approaching human cognition. It provides a novel way to measure semantic(More)
As a mammalian p-glycoprotein homolog, Pdr5p is a major ATP-binding cassette transporter for cellular detoxification in the yeast Saccharomyces cerevisiae. In this study, two novel loss-of-function mutations located adjacent to the ends of the predicted transmembrane helices of Pdr5p were identified. C793F and S1230L mutations considerably impaired the(More)
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