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Voltage-gated sodium (Na(v)) channels are essential for the rapid depolarization of nerve and muscle, and are important drug targets. Determination of the structures of Na(v) channels will shed light on ion channel mechanisms and facilitate potential clinical applications. A family of bacterial Na(v) channels, exemplified by the Na(+)-selective channel of(More)
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion(More)
In this demonstration, we will showcase Myria, our novel cloud service for big data management and analytics designed to improve productivity. Myria's goal is for users to simply upload their data and for the system to help them be self-sufficient data science experts on their data -- self-serve analytics. Using a web browser, Myria users can upload data,(More)
Autophagy dysregulation has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). The expression of LC3II and sequestosome 1 (P62) was progressively increased in the lumbar spinal cord of ALS mice. However, whether autophagy is activated or inhibited is still unclear. By treating mice with food restriction, a well-recognized way to(More)
Optical networks with flexible bandwidth provisioning are a very promising networking architecture. It enables efficient resource utilization and supports heterogeneous bandwidth demands. In this paper, we focus on the dynamic routing and spectrum allocation (RSA) problem which emerges in such networks and propose a novel dynamic RSA algorithm by means of(More)
H9N2 influenza viruses have been circulating worldwide in multiple avian species and have repeatedly infected humans to cause typical disease. The continued avian-to-human interspecies transmission of H9N2 viruses raises concerns about the possibility of viral adaption with increased virulence for humans. To investigate the genetic basis of H9N2 influenza(More)
The genomes of six pigeon paramyxovirus type 1 (PPMV-1) isolated from symptomless pigeons in live poultry markets during the national active surveillance from 2011 to 2013 were sequenced and analyzed in this study. The complete genome lengths of all isolates were 15,192 nucleotides with the gene order of 3'-NP-P-M-F-HN-L-5'. All isolates had the same motif(More)
In this paper, we determine the channel capacity of a 60 GHz wireless communications system for the CM1 and CM2 channel models defined by the IEEE 802.15.3c Task Group. Two transmitter (Tx) and receiver (Rx) antenna models are considered. It is shown that the capacity in channel CM1 is greater than that in channel CM2. In addition, changing the half power(More)
Chronic inflammation induced by endotoxin from a dysbiotic gut microbiota contributes to the development of obesity-related metabolic disorders. Modification of gut microbiota by a diet to balance its composition becomes a promising strategy to help manage obesity. A dietary scheme based on whole grains, traditional Chinese medicinal foods, and prebiotics(More)