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PURPOSE Recent studies showed that oncolytic adenoviruses not only have capacity for destruction of tumors but also can be used as potential vectors to express therapeutic genes for therapy of cancer. However, better specificity and mode of transgene expression are required to improve the efficacy and safety if this vector is applied for clinical(More)
PURPOSE Recent studies have indicated that short hairpin RNA (shRNA) driven by RNA polymerase (Pol) II promoters can be transcribed into precursor mRNAs together with transgenes. It remains unclear, however, whether coexpression of shRNA and transgene from a single promoter is feasible for cancer therapy. EXPERIMENTAL DESIGN In this study, we generated(More)
Lectins exist widely in marine bioresources such as bacteria, algae, invertebrate animals and fishes. Some purified marine lectins have been found to elicit cytotoxicity to cancer cells. However, there are few reports describing the cytotoxic effect of marine lectins on cancer cells through virus-mediated gene delivery. We show here that a(More)
Our previous studies have suggested that harboring a soluble coxsackie-adenovirus receptor-ligand (sCAR-ligand) fusion protein expression cassette in the viral genome may provide a universal method to redirect oncolytic adenoviruses to various membrane receptors on cancer cells resisting to serotype 5 adenovirus infection. We report here a novel oncolytic(More)
correlates with recurrence within five years of surgery. To investigate the role of Notch signalling in tumour progression, characterized by increased proliferation, apoptosis resistance, epithelial–mesenchymal transition (EMT) and loss of polarity in 3D cultures, we have created an inducible NICD over-expressing MCF10A cell line. Furthermore, we have(More)
correlates with recurrence within five years of surgery. To investigate the role of Notch signalling in tumour progression, characterized by increased proliferation, apoptosis resistance, epithelial–mesenchymal transition (EMT) and loss of polarity in 3D cultures, we have created an inducible NICD over-expressing MCF10A cell line. Furthermore, we have(More)
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