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Variants of the MSTN gene encoding myostatin are associated with muscle hypertrophy phenotypes in a range of mammalian species, most notably cattle, dogs, mice, and humans. Using a sample of registered Thoroughbred horses (n = 148), we have identified a novel MSTN sequence polymorphism that is strongly associated (g.66493737C>T, P = 4.85x10(-8)) with best(More)
Thoroughbred horses have been selected for traits contributing to speed and stamina for centuries. It is widely recognized that inherited variation in physical and physiological characteristics is responsible for variation in individual aptitude for race distance, and that muscle phenotypes in particular are important. A genome-wide SNP-association study(More)
Thoroughbred horses have been selected for exceptional racing performance resulting in system-wide structural and functional adaptations contributing to elite athletic phenotypes. Because selection has been recent and intense in a closed population that stems from a small number of founder animals Thoroughbreds represent a unique population within which to(More)
The widespread application of cloud computing creates massive application services on the Internet, which is a new challenge for the models and algorithms of cloud service composition. This paper proposes a new method for cloud service composition. Time attenuation function is added into the service composition model, and service composition is formalized(More)
Selective breeding for speed in the racehorse has resulted in an unusually high frequency of the C-variant (g.66493737C/T) at the myostatin gene (MSTN) in cohorts of the Thoroughbred horse population that are best suited to sprint racing. Here we show using a combination of molecular- and pedigree-based approaches in 593 horses from 22 Eurasian and(More)
Multi-objective optimization has been a difficult problem and a research focus in the field of science and engineering. This paper presents a novel multi-objective optimization algorithm called elite-guided multi-objective artificial bee colony (EMOABC) algorithm. In our proposal, the fast non-dominated sorting and population selection strategy are applied(More)
Location information is crucial in the wireless sensor network. The nodes in wireless sensor networks are often deployed in the three-dimensional scenario. Therefore, the three-dimensional localization algorithm has become hot in wireless sensor networks. However, existing 3D localization algorithms have shortcomings, such as high complexity, low(More)
Sequence variation at the equine myostatin gene (MSTN) locus has previously been shown to have a singular genomic influence on optimum race distance in Thoroughbred racehorses. Myostatin, encoded by the MSTN gene, is a member of the TGF-β superfamily that regulates skeletal muscle development in a range of mammalian species including the horse. In the(More)