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BACKGROUND Previous MRI studies of healthy children have reported age-related white matter (WM) changes in language and motor areas of the brain. The authors investigated WM development in healthy adolescent males through age-associated changes in fractional anisotropy (FA), radial (lambda( perpendicular)) and axial (lambda(||)) diffusivity. METHODS(More)
CONTEXT There is increasing evidence that schizophrenia is characterized by abnormalities in white matter. OBJECTIVE To investigate the integrity of white matter tracts in adolescents with schizophrenia. DESIGN Cross-sectional, case-control, whole-brain, voxel-based analysis and fiber tractography using diffusion tensor magnetic resonance imaging. (More)
There is evidence from post-mortem and magnetic resonance imaging studies that hyperintensities, oligodendroglial abnormalities, and gross white matter volumetric alterations are involved in the pathophysiology of bipolar disorder. There is also functional imaging evidence for a defect in frontal cortico-subcortical pathways in bipolar disorder, but the(More)
OBJECTIVE To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18). METHOD Twenty-six patients with schizophrenia and 34 age- and gender-matched healthy volunteers received diffusion tensor imaging and structural(More)
BACKGROUND Impulsivity is characteristic of individuals with bipolar disorder and may be a contributing factor to the high rate of suicide in patients with this disorder. Although white matter abnormalities have been implicated in the pathophysiology of bipolar disorder, their relationship to impulsivity and suicidality in this disorder has not been(More)
This paper introduces a new unambiguous, cost effective discriminator that maintains the multipath mitigation property of Binary Offset Carrier (n,n) signals such as BOC(1,1). The paper evaluates the multipath mitigation performance of different discriminators (including the “BOC-PRN (Early + Late)” discriminator). The new discriminator is based on the(More)
Collective Detection is a position domain detection algorithm that combines simultaneous signals from multiple satellites onto a geographical search space for acquisition, and provides a position estimate as a by-product of the Maximum Likelihood detection process. This results in increased peak-tonoise ratio in the combined cost function and has been(More)