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Certain receptive field properties of cortical neurons depend upon inhibitory, GABAergic inputs. In the somatosensory cortex, iontophoresis of bicuculline, a GABAA receptor blocker, results in enlargement of receptive fields. However, bicuculline's effectiveness in changing receptive field size varies with the neuron's adaptation characteristics, location(More)
A large number of quantitative trait loci (QTL) for resistance to late blight of potato have been reported with a “conventional” method in which each phenotypic trait reflects the cumulative genetic effects for the duration of the disease process. However, as genes controlling response to disease may have unique contributions with specific temporal(More)
The present investigation assessed whether hypnotic activity of melatonin was mediated by the GABA(A) receptor in rats. Electroencephalography (EEG) was measured in this experiment. Melatonin, at a dose of 10 mg/kg ip, showed a significant sleep-promoting effect in rats. Flumazenil (3.5 and 7 mg/kg), a specific antagonist of the benzodiazepine (BZP)(More)
Previous studies showed that inflammation and apoptosis were involved in the pathogenesis of hypoxic-ischemic brain injury. The immature brain is particularly vulnerable to damage. Intracerebral injection of glial cell line-derived neurotrophic factor (GDNF) has been shown to reduce the injury induced by hypoxia-ischemia (HI). In this study, the(More)
The primary somatosensory (SI) cortex in the cat contains four cytoarchitectonic areas that appear to contain separate body representations and have different functions. We tested whether functional differences among these areas are reflected in the densities of neurons containing each of three calcium-binding proteins: parvalbumin (PV), calbindin (CB), and(More)
Inhibition in primary sensory cortex plays a role in neuronal responses to peripheral stimuli. For many neurons in cat primary somatosensory cortex, blockade of GABAA receptors by bicuculline results in receptive field enlargement. The magnitude of this effect varies with the neuron's adaptation characteristics and its location in particular laminae and(More)
The aim of this study was to increase marker density in a previously identified late blight resistance QTL in a diploid potato population. SSR markers from the reference potato genome sequence were located by e-PCR in the QTL region in the chromosome 9 genetic map of the diploid potato population B3C1HP, and utilized to identify more candidate genes(More)
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