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Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats
The organ concentration of BBR (as well as its bioactive metabolites) was higher than its concentration in the blood after oral administration, which might explain BBR’s pharmacological effects on human diseases in clinic. Expand
BF3·Et2O catalyzed diastereoselective nucleophilic reactions of 3-silyloxypiperidine N,O-acetal with silyl enol ether and application to the asymmetric synthesis of (+)-febrifugine
Abstract The asymmetric BF 3 ·Et 2 O catalyzed nucleophilic reactions of 3-silyloxypiperidine N , O -acetal 10 with silyl enol ethers derived from ketones are described. (+)-Febrifugine 1 , anExpand
[Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats].
The results suggested that echinacoside could promote the recovery of cholinergic neurotransmitter levels in vascular dementia rats' brain, which may be one of the mechanisms of neuro-protection. Expand
Identification of metabolites of FR429, a potential antitumor ellagitannin, transformed by rat intestinal bacteria in vitro, based on liquid chromatography-ion trap-time of flight mass spectrometry
It is demonstrated that FR429 could be transformed by intestinal bacteria in vitro, mainly via hydrolysis and reduction reaction, and provided a basis for the further study on the biotansformation of FR429 in vivo. Expand
Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human
Molecular docking study confirmed the inhibition modes of HM-1 on these human CYP isoforms andHM-1 competitively inhibited testosterone 6β-hydroxylation but displayed mixed type inhibitions for phenacetin O-deethylation (CYP1A2) and tolbutamide 4-hydroxy-2,3,5-trimethoxy-xanthone (Cyp2C9). Expand
In vitro study on metabolite profiles of bioactive xanthones isolated from Halenia elliptica D. Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry.
High performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry (LC-ESI-IT-TOF) was applied for identification of metabolites of five xanthones mentioned above and (1)H NMR was used to elucidate the major metabolites. Expand
In vitro identification of cytochrome P450 isoforms responsible for the metabolism of 1-hydroxyl-2,3,5-trimethoxy-xanthone purified from Halenia elliptica D. Don.
Evidence of substrate inhibition and metabolism-based drug-drug interaction for the medicinal preparations containing HM-1 used in clinic is provided, which demonstrated that demethylation and hydroxylation were the major Phase I metabolic reactions forHM-1 in HLMs. Expand
A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine
Abstract An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychoticExpand
Oral administration of a mixture of probiotics protects against food allergy via induction of CD103+ dendritic cells and modulates the intestinal microbiota
Treatment with the probiotics attenuated OVA-induced allergic symptoms in mice and provided molecular insight into the application of a mixture of probiotics to alleviate food allergies and even gut immune homeostasis. Expand
Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro.
The in vitro metabolism pathways of FR429 were hydrolysis, methylation and sulfation, a reported anti-angiogenic agent, and the anti-tumor effects of its major metabolites should be further studied. Expand