Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
- S. Nauli, F. Alenghat, Jing Zhou
- Biology, MedicineNature Genetics
- 1 February 2003
PC1 and PC2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both function in the same mechanotransduction pathway, suggesting loss or dysfunction of PC1 or PC2 may lead to polycystic kidney disease.
Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation
- Tatiana Y. Besschetnova, E. Kolpakova-Hart, Y. Guan, Jing Zhou, B. Olsen, J. Shah
- BiologyCurrent Biology
- 26 January 2010
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
- Benjamin S. Freedman, C. Brooks, J. Bonventre
- BiologyNature Communications
- 23 October 2015
It is shown that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes after genome editing, establishing a reproducible, versatile three-dimensional framework for human epithelial disease modelling and regenerative medicine applications.
Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1
- S. Nauli, Y. Kawanabe, John J. Kaminski, W. Pearce, D. Ingber, Jing Zhou
- Biology, MedicineCirculation
- 4 March 2008
It is demonstrated for the first time that polycystin-1 and polaris are crucial mechanosensitive molecules in endothelial cells and that a distinctive communication with the extracellular microenvironment depends on the proper localization and function of polycyStin- 1 in cilia.
Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
- Weining Lu, B. Peissel, Jing Zhou
- Biology, MedicineNature Genetics
- 1 October 1997
The timing of cyst formation indicates that full-length polycystin is required for normal morphogenesis during elongation and maturation of tubular structures in the kidney and pancreas.
Polycystins and primary cilia: primers for cell cycle progression.
- Jing Zhou
- Biology, MedicineAnnual Review of Physiology
- 12 February 2009
This review discusses recent topics in polycystin research, with a focus on the role of polyCystin-1 and polycyStin-2 in primary cilia and the cell cycle.
Aberrant regulation of planar cell polarity in polycystic kidney disease.
It is shown that inactivation of Pkd1 in postnatal developing mouse kidneys leads to a defect in oriented cell division in precystic kidney tubules, and that aberrant PCP signaling contributes to cystogenesis.
Polycystins and mechanosensation in renal and nodal cilia
This review will summarize the recent breakthroughs in PKD research and discuss the role(s) of th polycystin signaling complex in mediating mechanosensory function by the primary cilium of renal epithelium as well as of the embryonic node.
Gating of the polycystin ion channel signaling complex in neurons and kidney cells
PC1 acts as a prototypical membrane receptor that concordantly regulates PC2 channels and G‐proteins, a bimodal mechanism that may account for the multifunctional roles of polycystin proteins in fundamental cellular processes of various cell types.
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
- A. Takakura, E. Nelson, Jing Zhou
- Medicine, BiologyHuman Molecular Genetics
- 5 August 2011
The results suggest that PC1 acts as a negative regulator of STAT3 and that blocking STAT3 signaling with pyrimethamine or similar drugs may be an attractive therapy for human ADPKD.
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