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Machine learning and data mining are gaining increasing attentions of the computing society. FPGA provides a highly parallel, low power, and flexible hardware platform for this domain, while the difficulty of programming FPGA greatly limits its prevalence. MapReduce is a parallel programming framework that could easily utilize inherent parallelism in(More)
Myosin X (MyoX), encoded by Myo10, is a representative member of the MyTH4-FERM domain-containing myosins, and this family of unconventional myosins shares common functions in promoting formation of filopodia/stereocilia structures in many cell types with unknown mechanisms. Here, we present the structure of the MyoX MyTH4-FERM tandem in complex with the(More)
—Stereo vision is a well-known technique for acquiring depth information. In this paper, we propose a real-time high-quality stereo vision system in FPGA (field programmable gate array). By using AD-Census cost initialization, cross-based cost aggregation and semi-global optimization, the system provides high-quality depth results for high-definition(More)
Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, require Ufd2 enzyme. Yeast cells lacking UFD2 exhibit(More)
BACKGROUND/AIMS To characterize IL-17-producing cells, a newly defined T helper cell subset with potent pro-inflammatory properties, in hepatocellular carcinoma (HCC) and to determine their prognostic values. METHODS One hundred and seventy-eight HCC patients were enrolled randomly. Distribution and phenotypic features of IL-17-producing cells were(More)
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study,(More)
BACKGROUND The increase in childhood obesity is a serious public health concern. Several studies have indicated that breastfed children have a lower risk of childhood obesity than those who were not breastfed, while other studies have provided conflicting evidence. The objective of this meta-analysis was to investigate the association between breastfeeding(More)
Drought and salt stress severely inhibit plant growth and development; however, the regulatory mechanisms of plants in response to these stresses are not fully understood. Here we report that the expression of a WRKY transcription factor WRKY46 is rapidly induced by drought, salt and oxidative stresses. T-DNA insertion of WRKY46 leads to more sensitivity to(More)
IMPORTANT: this document contains embedded data-to preserve data integrity, please ensure where possible that the IUCr Word tools (available from We computed and evaluated total of 1276 features/inputs for fDETECT that include: Amino acid based (420 features). Features based on amino acid (AA) types. − AAComposition_{AA} –composition (count) of a given AA(More)
In neurons, microtubules (MTs) span the length of both axons and dendrites, and the molecular motors use these intracellular 'highways' to transport diverse cargo to the appropriate subcellular locations. Whereas axonal MTs are organized such that the plus-end is oriented out from the cell body, dendrites exhibit a mixed MTs polarity containing both(More)