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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
TLDR
It is shown that leukaemia stem cells (LSC) can maintain the global identity of the progenitor from which they arose while activating a limited stem-cell- or self-renewal-associated programme. Expand
AlleleSeq: analysis of allele-specific expression and binding in a network framework
TLDR
A computational pipeline is developed that identifies allele‐specific events with significant differences in the number of mapped reads between maternal and paternal alleles, and investigates the coordination between ASE and ASB from multiple transcription factors events using a regulatory network framework. Expand
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
TLDR
This paper identifies diverse cell types, including multiple progenitor and neuronal subtypes, and identifies EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia by microfluidic single-cell capture and low-coverage sequencing of many cells. Expand
High-Level Production of Beta-Carotene in Saccharomyces cerevisiae by Successive Transformation with Carotenogenic Genes from Xanthophyllomyces dendrorhous
TLDR
It is succeeded in constructing an S. cerevisiae strain capable of producing high levels of β-carotene, up to 5.9 mg/g (dry weight), which was accomplished by the introduction of an additional copy of crtI and tHMG1 into carotenoid-producing yeast cells. Expand
Single cell RNA Seq reveals dynamic paracrine control of cellular variation
TLDR
This study highlights the importance of cell-to-cell communication in controlling cellular heterogeneity and reveals general strategies that multicellular populations can use to establish complex dynamic responses. Expand
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.
TLDR
In conclusion, inhibition of the p38 MAPK pathway by SB203580 overcomes the block in deriving ES cells from blastocysts lacking a functional Alk3, the BMP type IA receptor, and uncover a paradigm for BMP signaling in the biology of pluripotent stem cells. Expand
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
TLDR
This method uses the T4 bacteriophage β-glucosyltransferase to transfer an engineered glucose moiety containing an azide group onto the hydroxyl group of 5-hmC, a recently identified epigenetic modification present in substantial amounts in certain mammalian cell types. Expand
Crystal structure of the clathrin adaptor protein 1 core.
TLDR
The crystal structure of the core of the AP-1 complex, which functions in the trans-Golgi network (TGN), is reported and it is shown that directed mutations of residues at a particular corner of the gamma chain prevent recruitment to the TGN in cells and diminish PI-4-P- dependent, but not Arf1-dependent, liposome binding in vitro. Expand
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
TLDR
ARV-825 is designed, a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation ofBRD4 in all BL cell lines tested. Expand
A new phylogeny for the genus Picea from plastid, mitochondrial, and nuclear sequences.
TLDR
The large effective population sizes of spruces, and incomplete lineage sorting during speciation, mean that the interspecific relationships within each of the geographic clades require further studies, especially based on genomic information and population genetic data. Expand
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