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Functional enrichment analysis is an essential task for the interpretation of gene lists derived from large-scale genetic, transcriptomic and proteomic studies. WebGestalt (WEB-based GEne SeT AnaLysis Toolkit) has become one of the popular software tools in this field since its publication in 2005. For the last 7 years, WebGestalt data holdings have grown(More)
Members of the HCN channel family generate hyperpolarization-activated cation currents (Ih) that are directly regulated by cAMP and contribute to pacemaker activity in heart and brain. The four HCN isoforms show distinct but overlapping patterns of expression in different tissues. Here, we report that HCN1 and HCN2, isoforms coexpressed in neocortex and(More)
Increasing crop yield is a major challenge for modern agriculture. The development of new plant types, which is known as ideal plant architecture (IPA), has been proposed as a means to enhance rice yield potential over that of existing high-yield varieties. Here, we report the cloning and characterization of a semidominant quantitative trait locus, IPA1(More)
Lithium is commonly used to treat bipolar disorder, which is associated with altered circadian rhythm. Lithium is a potent inhibitor of glycogen synthase kinase 3 (GSK3), which regulates circadian rhythm in several organisms. In experiments with cultured cells, we show here that GSK3beta phosphorylates and stabilizes the orphan nuclear receptor(More)
In hyperspectral image analysis, the principal components analysis (PCA) and the maximum noise fraction (MNF) are most commonly used techniques for dimensionality reduction (DR), referred to as PCA-DR and MNF-DR, respectively. The criteria used by the PCA-DR and the MNF-DR are data variance and signal-to-noise ratio (SNR) which are designed to measure data(More)
The genetic diversity of Yersinia pestis, the etiologic agent of plague, is extremely limited because of its recent origin coupled with a slow clock rate. Here we identified 2,326 SNPs from 133 genomes of Y. pestis strains that were isolated in China and elsewhere. These SNPs define the genealogy of Y. pestis since its most recent common ancestor. All but(More)
Since their arrival in the Tibetan Plateau during the Neolithic Age, Tibetans have been well-adapted to extreme environmental conditions and possess genetic variation that reflect their living environment and migratory history. To investigate the origin of Tibetans and the genetic basis of adaptation in a rigorous environment, we genotyped 30 Tibetan(More)
Independent component analysis (ICA) has shown success in many applications. This paper investigates a new application of the ICA in endmember extraction and abundance quantification for hyperspectral imagery. An endmember is generally referred to as an idealized pure signature for a class whose presence is considered to be rare. When it occurs, it may not(More)
Manifold learning algorithms seek to find a low-dimensional parameterization of high-dimensional data. They heavily rely on the notion of what can be considered as local, how accurately the manifold can be approximated locally, and, last but not least, how the local structures can be patched together to produce the global parameterization. In this paper, we(More)
The semantic gap between low-level visual features and high-level semantics has been investigated for decades but still remains a big challenge in multimedia. When "search" became one of the most frequently used applications, "intent gap", the gap between query expressions and users' search intents, emerged. Researchers have been focusing on three(More)