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Crowdsourcing services, such as Amazon Mechanical Turk, allow for easy distribution of small tasks to a large number of workers. Unfortunately, since manually verifying the quality of the submitted results is hard, malicious workers often take advantage of the verification difficulty and submit answers of low quality. Currently, most requesters rely on(More)
—In hyperspectral image analysis, the principal components analysis (PCA) and the maximum noise fraction (MNF) are most commonly used techniques for dimensionality reduction (DR), referred to as PCA-DR and MNF-DR, respectively. The criteria used by the PCA-DR and the MNF-DR are data variance and signal-to-noise ratio (SNR) which are designed to measure data(More)
Functional enrichment analysis is an essential task for the interpretation of gene lists derived from large-scale genetic, transcriptomic and proteomic studies. WebGestalt (WEB-based GEne SeT AnaLysis Toolkit) has become one of the popular software tools in this field since its publication in 2005. For the last 7 years, WebGestalt data holdings have grown(More)
Lithium is commonly used to treat bipolar disorder, which is associated with altered circadian rhythm. Lithium is a potent inhibitor of glycogen synthase kinase 3 (GSK3), which regulates circadian rhythm in several organisms. In experiments with cultured cells, we show here that GSK3beta phosphorylates and stabilizes the orphan nuclear receptor(More)
A number of studies have investigated differences in neural correlates of abstract and concrete concepts with disagreement across results. A quantitative, coordinate-based meta-analysis combined data from 303 participants across 19 functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies to identify the differences in(More)
This paper presents a robust adaptive neural control design for a class of perturbed strict feedback nonlinear system with both completely unknown virtual control coefficients and unknown nonlinearities. The unknown nonlinearities comprise two types of nonlinear functions: one naturally satisfies the "triangularity condition" and can be approximated by(More)
OBJECTIVE Recently, genome-wide association studies have provided evidence that several common variants within the fat mass-and obesity-associated (FTO) gene were significantly associated with obesity in populations of European origin. However, their effects in other ethnic populations remain to be elucidated. RESEARCH DESIGN AND METHODS In this study, we(More)
BACKGROUND Housekeeping (HK) genes are ubiquitously expressed in all tissue/cell types and constitute a basal transcriptome for the maintenance of basic cellular functions. Partitioning transcriptomes into HK and tissue-specific (TS) genes relatively is fundamental for studying gene expression and cellular differentiation. Although many studies have aimed(More)