Erianin inhibits the proliferation of T47D cells by inhibiting cell cycles, inducing apoptosis and suppressing migration.
It is demonstrated that Erianin might have the potential to be an effective drug to treat the ER positive breast cancer.
Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice
- Jing Sun, Yongsen Wang, Guodong Li
- Biology, ChemistryBioMed Research International
- 7 May 2015
Findings indicated that improvement of insulin sensitivity and hypoglycemic effects of ME may be attributed to the inhibition of PTP1B, which is an established therapeutic target for type 2 diabetes mellitus (T2DM) and obesity.
The positive feedback between lncRNA TNK2-AS1 and STAT3 enhances angiogenesis in non-small cell lung cancer.
- Yue Wang, Dongmei Han, Liming Pan, Jing Sun
- Biology, ChemistryBiochemical and Biophysical Research…
- 1 December 2018
Dendrobium candidum inhibits MCF-7 cells proliferation by inducing cell cycle arrest at G2/M phase and regulating key biomarkers
D. candidum could decrease the cell viability of MCF-7 cells by inducing cell cycle arrest at the G2/M phase and regulating the key biomarkers in breast cancer cells.
LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis
- Jing Sun, Liming Pan, Li-bo Chen, Yue Wang
- BiologyCell Cycle
- 29 September 2017
It is suggested that lncRNA XIST may be a new marker of poor response to cisplatin and could be a potential therapeutic target for LAD chemotherapy.
Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice
Honokiol exhibited reversible competitive inhibitory activity against PTP1B with good selectivity in vitro and in vivo, and may highlight as a promising insulin sensitizer for the therapy of type 2 diabetes.
GATA2 regulates GATA1 expression through LSD1-mediated histone modification.
Observations reveal an elegant mechanism to modulate GATA1 and GATA2 expression during erythroid differentiation, demonstrating that LSD1 represses GATA 1 expression through LSD1-mediated histone demethylation.
lncRNA TINCR attenuates the proliferation and invasion, and enhances the apoptosis of cutaneous malignant melanoma cells by regulating the miR-424-5p/LATS1 axis
- Xuemei Han, Yuxi Jia, Xiangru Chen, Chengkuan Sun, Jing Sun
- BiologyOncology Report
- 20 September 2021
It is suggested that TINCR may attenuate the progression of CMM by regulating the miR-424-5p/LATS1 signaling axis and inhibit the expression levels of CTGF, CCN1 and AXL.
A C118T polymorphism of ERCC1 and response to cisplatin chemotherapy in patients with late-stage non-small cell lung cancer
- Jian Cheng, Minwen Ha, C. Tong
- Biology, MedicineJournal of Cancer Research and Clinical Oncology
- 1 February 2012
The results suggest that this polymorphism of ERCC1 at codon 118 is associated with patient response to cisplatin-based chemotherapy in treatments of late-stage NSCLC and may represent a valuable biomarker in developing individualized treatments forNSCLC patients.
Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation
The data revealed that LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 locus, and it was demonstrated that LSD 1 binds to the 1S promoter of theGATA- 2 locus and suppresses Gata-2 expression, via histone demethylation.
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