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Comprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimesExpand
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From fly wings to targeted cancer therapies: a centennial for notch signaling.
Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety ofExpand
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Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic progression remain poorly understood. We isolated pure populations of cancer cells from primary tumors andExpand
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CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.
Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited treatment options. CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatoryExpand
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Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer
The Notch signalling pathway mediates cell fate decisions and is tumour suppressive or oncogenic depending on the context. During lung development, Notch pathway activation inhibits theExpand
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Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.
Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-termExpand
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Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin.
The extent to which early events shape tumor evolution is largely uncharacterized, even though a better understanding of these early events may help identify key vulnerabilities in advanced tumors.Expand
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Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models.
Small cell lung carcinoma (SCLC) is a fast-growing, highly metastatic form of lung cancer. A major difference between SCLC and other forms of lung cancer is that SCLC tumors often respond well toExpand
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CD 47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited treatment options. CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatoryExpand
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Small Cell Lung Cancer subtypes identified by systems-level modeling of transcription factor networks
Small-cell lung cancer (SCLC) is characterized by rapid progression, early metastasis, and poor standard-of-care outcomes. Recent investigations have uncovered SCLC heterogeneity, but have notExpand
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