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Alternative RNA splicing greatly increases proteome diversity and may thereby contribute to tissue-specific functions. We carried out genome-wide quantitative analysis of alternative splicing using a custom Affymetrix microarray to assess the role of the neuronal splicing factor Nova in the brain. We used a stringent algorithm to identify 591 exons that(More)
  • Christian R H Raett, William Dowhan, Nan Wang, Kun Yan, Mark M Rasenick, Harry B Smith +313 others
  • 2001
MINIREVIEW Biosynthesis and function of phospholipids in Esch-erichia coli. COMMUNICATIONS Tubulin binds specifically to the signal-transducing proteins, G, and Gi.1. An engineered change in substrate specificity of ribulosebisphosphate carboxylase/oxygenase. Stimulation of glycine catabolism in isolated per-fused rat liver by calcium mobilizing hormones(More)
MOTIVATION Alternative splicing allows a single gene to generate multiple mRNAs, which can be translated into functionally and structurally diverse proteins. One gene can have multiple variants coexisting at different concentrations. Estimating the relative abundance of each variant is important for the study of underlying biological function. Microarrays(More)
MOTIVATION Many or most mammalian genes undergo alternative splicing, generating a variety of transcripts from a single gene. New information on splice variation is becoming available through technology for measuring expression levels of several exons or splice junctions per gene. We have developed a statistical method, ANalysis Of Splice VAriation (ANOSVA)(More)
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