• Publications
  • Influence
The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases
Cerebral cavernous malformation (CCM) is a common vascular dysplasia that affects both systemic and central nervous system blood vessels. Loss of function mutations in the CCM2 gene cause CCM. HereExpand
  • 283
  • 24
Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.
Cerebral cavernous malformations (CCMs) are a common type of vascular malformation in the brain that are a major cause of hemorrhagic stroke. This condition has been independently linked to 3Expand
  • 85
  • 13
  • PDF
Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation
Background— Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A subset of patients have aExpand
  • 87
  • 4
  • PDF
Small Molecule Activator of the Human Epithelial Sodium Channel*
The epithelial sodium channel (ENaC), a heterotrimeric complex composed of α, β, and γ subunits, belongs to the ENaC/degenerin family of ion channels and forms the principal route for apical Na+Expand
  • 41
  • 3
  • PDF
Proteasome function is required for platelet production.
The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how theExpand
  • 42
  • 1
  • PDF
Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats
Vascular complications are the leading causes of morbidity and mortality in diabetes mellitus (DM). The RAGE (receptor for advanced glycation end products)-NADPH oxidase-NF-κB signal transductionExpand
  • 26
  • 1
ARF6 Inhibition Stabilizes the Vasculature and Enhances Survival during Endotoxic Shock
The vascular endothelium responds to infection by destabilizing endothelial cell–cell junctions to allow fluid and cells to pass into peripheral tissues, facilitating clearance of infection andExpand
  • 24
  • 1
Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness
Increased large artery stiffness is a hallmark of arterial dysfunction with advancing age and is also present in other disease conditions such as diabetes. Increased large artery stiffness isExpand
  • 13
  • 1
Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy
The devastating sequelae of diabetes mellitus include microvascular permeability, which results in retinopathy. Despite clinical and scientific advances, there remains a need for new approaches toExpand
  • 14
  • 1
  • PDF
Application of High-Throughput Sequencing in the Diagnosis of Inherited Thrombocytopenia
Inherited thrombocytopenia is a group of hereditary diseases with a reduction in platelet count as the main clinical manifestation. Clinically, there is an urgent need for a convenient and rapidExpand
  • 5
  • 1