Learn More
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel fibre-optic(More)
Cross talk between salicylic acid (SA)- and jasmonic acid (JA)-dependent defense signaling has been well documented in plants, but how this cross talk is executed and the components involved remain to be elucidated. We demonstrate that the plant-specific transcription factor WRKY70 is a common component in SA- and JA-mediated signal pathways. Expression of(More)
In order to increase our ability to use measurement to support software development practise we need to do more analysis of code. However, empirical studies of code are expensive and their results are difficult to compare. We describe the Qualitas Corpus, a large curated collection of open source Java systems. The corpus reduces the cost of performing large(More)
Rapid advances in neuroimaging techniques provide great potentials for study of Alzheimer's disease (AD). Existing findings have shown that AD is closely related to alteration in the functional brain network, i.e., the functional connectivity between different brain regions. In this paper, we propose a method based on sparse inverse covariance estimation(More)
Cross-talk between signal transduction pathways is a central feature of the tightly regulated plant defense signaling network. The potential synergism or antagonism between defense pathways is determined by recognition of the type of pathogen or pathogen-derived elicitor. Our studies have identified WRKY70 as a node of convergence for integrating salicylic(More)
Plant innate immunity depends in part on recognition of pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin, EF-Tu, and fungal chitin. Recognition is mediated by pattern-recognition receptors (PRRs) and results in PAMP-triggered immunity. EF-Tu and flagellin, and the derived peptides elf18 and flg22, are recognized in Arabidopsis by(More)
Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease, compromising both native and transplanted kidneys. Treatment is limited because of a complex pathogenesis, including unknown serum factors. Here we report that serum soluble urokinase receptor (suPAR) is elevated in two-thirds of subjects with primary FSGS, but not in people(More)
To the editor: High-throughput metabolic profiling, known as metabolomics1 or metabonomics2, has been an active area of research for over 35 years3. The most commonly employed analytical tools, nuclear magnetic resonance (NMR)4 and mass spectrometry (MS)5, have been used extensively to study metabolites in a wide range of biological systems. Despite this(More)
This paper investigates the diversity gain offered by implementing network coding (R. Ahlswede et al., 2000) over wireless communication links. The network coding algorithm is applied to both a wireless network containing a distributed antenna system (DAS) as well as one that supports user cooperation between users. The results show that network-coded DAS(More)
Programmed cell death (PCD) is a central regulatory process in both plant development and in plant responses to pathogens. PCD requires a coordinate activation of pro-apoptotic factors such as proteases and suppressors inhibiting and modulating these processes. In plants, various caspase-like cysteine proteases as well as serine proteases have been(More)