Jing-Hui Lei

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CONTEXT Plasma corticosteroid-binding globulin (CBG) transports cortisol but high progesterone levels at the maternal-fetal interface can displace cortisol from its steroid-binding site. A secretion-deficient CBG mutant (A51V) in ∼1 of 36 Chinese causes low circulating CBG levels. OBJECTIVE Assess the implications of a CBG deficiency on pregnancy(More)
CONTEXT Cortisol is transported by corticosteroid-binding globulin (CBG) in blood. Single nucleotide polymorphisms (SNP) in the human CBG (SERPINA6) gene that disrupt CBG production or steroid binding are considered rare. OBJECTIVE The objective of the study was to identify and determine the frequency of SNP in SERPINA6 that influence the production or(More)
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