Stephen M Strakowski10
Caleb M Adler7
Wen-Jang Chu6
Melissa P DelBello6
10Stephen M Strakowski
7Caleb M Adler
6Wen-Jang Chu
6Melissa P DelBello
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AIMS Impulsivity is common in bipolar disorder, especially during mania. Understanding the functional neuroanatomy of response inhibition, one component of impulsivity, might clarify the neural substrate of bipolar disorder. METHODS Sixteen DSM-IV first-episode, manic bipolar patients and 16 matched healthy subjects were examined during a first manic(More)
A general picture is presented of the implications for diffusion-weighted NMR signals of the parsimonious two-site-exchange (2SX) paradigm. In particular, it is shown that the diffusigraphic "shutter-speed," tau(-1) identical with |q(2)(D(A) - D(B))|, is a useful concept. The "wave-number" q has its standard definition (given in the text), and D(A) and D(B)(More)
Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level dependent] responses to activation stimuli.(More)
PURPOSE Magnetic resonance T1 -weighted images are routinely used for human brain segmentation, brain parcellation, and clinical diagnosis of demyelinating diseases. Myelin is thought to influence the longitudinal relaxation commonly described by a mono-exponential recovery, although reports of bi-exponential longitudinal relaxation have been published. The(More)
  • David E. Fleck, James C. Eliassen, Michelle Durling, Martine Lamy, Caleb M. Adler, Melissa P. DelBello +4 others
  • 2012
We examined sustained attention deficits in bipolar disorder and associated changes in brain activation assessed by functional magnetic resonance imaging (fMRI). We hypothesized that relative to healthy participants, those with mania or mixed mania would (1) exhibit incremental decrements in sustained attention over time, (2) overactivate brain regions(More)
BACKGROUND Bipolar I disorder is defined by the occurrence of mania. The presence of mania, coupled with a course of illness characterized by waxing and waning of affective symptoms, suggests that bipolar disorder arises from dysfunction of neural systems that maintain emotional arousal and homeostasis. We used functional magnetic resonance imaging (fMRI)(More)
PURPOSE To quantify the acoustic noise characteristics of a 4 Tesla MRI scanner, and determine the effects of structural acoustics and gradient pulse excitations on the sound field so that feasible noise control measures can be developed. MATERIALS AND METHODS Acoustic noise emissions were measured in the ear and mouth locations of a typical adult. The(More)
An NMR method is presented for measuring compartment-specific water diffusion coefficient (D) values. It uses relaxography, employing an extracellular contrast reagent (CR) to distinguish intracellular (IC) and extracellular (EC) (1)H(2)O signals by differences in their respective longitudinal (T(1)) relaxation times. A diffusion-weighted inversion-recovery(More)
OBJECTIVES This study used proton magnetic resonance spectroscopy ((1)H MRS) to evaluate the in vivo effects of extended-release divalproex sodium on the glutamatergic system in adolescents with bipolar disorder, and to identify baseline neurochemical predictors of clinical remission. METHOD Adolescents with bipolar disorder who were experiencing a manic(More)