Jing-Huei Lee

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Our algorithm contains two major steps: the intervertebral disk localization step, and the vertebra detection and segmentation step. In the first step, we apply a model-based searching method to approximately locate all the intervertebral disk clues between adjacent vertebrae of the whole spine and the best slice selection. A new approach using an intensity(More)
OBJECTIVE To determine whether cortical changes occur following participation in a program of modified constraint-induced movement therapy (mCIMT). DESIGN Pre-post, case series. SETTING Outpatient rehabilitation hospital. PARTICIPANTS Two men and 2 women with unilateral stroke occurring more than 1 year prior to study entry and moderate stable motor(More)
BACKGROUND Bipolar I disorder is defined by the occurrence of mania. The presence of mania, coupled with a course of illness characterized by waxing and waning of affective symptoms, suggests that bipolar disorder arises from dysfunction of neural systems that maintain emotional arousal and homeostasis. We used functional magnetic resonance imaging (fMRI)(More)
AIMS Impulsivity is common in bipolar disorder, especially during mania. Understanding the functional neuroanatomy of response inhibition, one component of impulsivity, might clarify the neural substrate of bipolar disorder. METHODS Sixteen DSM-IV first-episode, manic bipolar patients and 16 matched healthy subjects were examined during a first manic(More)
PURPOSE Magnetic resonance T1 -weighted images are routinely used for human brain segmentation, brain parcellation, and clinical diagnosis of demyelinating diseases. Myelin is thought to influence the longitudinal relaxation commonly described by a mono-exponential recovery, although reports of bi-exponential longitudinal relaxation have been published. The(More)
BACKGROUND Several lines of evidence suggest that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder, including prior studies indicating abnormalities in phosphometabolites. We examined abnormalities in biomarkers of cellular metabolism including adenosine triphosphate and adenosine diphosphate as well as the pH levels in the(More)
Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level dependent] responses to activation stimuli.(More)
PURPOSE To quantify the acoustic noise characteristics of a 4 Tesla MRI scanner, and determine the effects of structural acoustics and gradient pulse excitations on the sound field so that feasible noise control measures can be developed. MATERIALS AND METHODS Acoustic noise emissions were measured in the ear and mouth locations of a typical adult. The(More)
Although brain lactate levels are typically low and difficult to measure, a few previous investigators have reported that brain lactate levels are elevated in patients with bipolar disorder. The present study investigated the distribution of lactate in bipolar and healthy brains using 2D proton magnetic resonance spectroscopic imaging on a 4-Tesla magnetic(More)
Detecting brain structural changes from magnetic resonance (MR) images can facilitate early diagnosis and treatment of neurological and psychiatric diseases. Many existing methods require an accurate deformation registration, which is difficult to achieve and therefore prevents them from obtaining high accuracy. We develop a novel local feature based(More)