Learn More
Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these individuals was screened for CNV using two(More)
We define a new image feature called the color correlogram and use it for image indexing and comparison. This feature distills the spatial correlation of colors, and is both effective and inexpensive for content-based image retrieval. The correlogramrobustly tolerates large changes in appearance and shape caused by changes in viewing positions, camera(More)
We introduce a new iterative method for finding a common element of the set of solutions of a generalized equilibrium problem with a relaxed monotone mapping and the set of common fixed points of a countable family of nonexpansive mappings in a Hilbert space and then prove that the sequence converges strongly to a common element of the two sets. Using this(More)
p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation. Histone lysine methylation has recently been shown to be reversible; however, it is not known whether non-histone proteins are substrates for demethylation. Here we show that, in human cells, the histone(More)
Specific sites of lysine methylation on histones correlate with either activation or repression of transcription. The tumour suppressor p53 (refs 4-7) is one of only a few non-histone proteins known to be regulated by lysine methylation. Here we report a lysine methyltransferase, Smyd2, that methylates a previously unidentified site, Lys 370, in p53. This(More)
Changes in DNA copy number are one of the hallmarks of the genetic instability common to most human cancers. Previous micro-array-based methods have been used to identify chromosomal gains and losses; however, they are unable to genotype alleles at the level of single nucleotide polymorphisms (SNPs). Here we describe a novel algorithm that uses a recently(More)
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control(More)
Accumulating evidence suggests that microglial cells in the spinal cord play an important role in the development of neuropathic pain. However, it remains largely unknown how glia interact with neurons in the spinal cord after peripheral nerve injury. Recent studies suggest that the chemokine fractalkine may mediate neural/microglial interaction via its(More)
We define a new image feature called the color correlogram and use it for image indexing and comparison. This feature distills the spatial correlation of colors and when computed efficiently, turns out to be both effective and inexpensive for content-based image retrieval. The correlogram is robust in tolerating large changes in appearance and shape caused(More)