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The objective of this study was to evaluate the feasibility of producing 10-hydroxycamptothecin nanosuspensions with high drug payload and to then determine the in vitro and in vivo characteristics of these nanosuspensions. Using cholesterol-PEG600 as a stabilizer, 10-hydroxycamptothecin nanosuspensions were successfully prepared using a(More)
In this study, polyethylene glycol (PEG)ylated 10-hydroxycamptothecin (mPEG1000-HCPT) was synthesized and used as a stabilizer to prepare 10-hydroxycamptothecin (HCPT) nanosuspensions for their in vitro and in vivo antitumor investigation. The resultant HCPT nanosuspensions (HCPT-NSps) had a very high drug payload of 94.90% (w/w) and a mean particle size of(More)
In this paper, the optical properties of gold nanorods (GNRs) tuned by lead sulfide (PbS) were studied. GNRs used in this work were synthesized by seed-mediated methods. Using electrostatic self-assembly methods, GNRs were modified by repetition of adsorbing oppositely charged polyelectrolyte. Then GNR-PbS nanostructure was fabricated by alternatively(More)
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