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We present a new approach for the analysis of the left ventricular shape and motion based on the development of a new class of volumetric deformable models. We estimate the deformation and complex motion of the left ventricle (LV) in terms of a few parameters that are functions and whose values vary locally across the LV. These parameters capture the radial(More)
BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has been shown to exert a synergistic antitumor effect when combined with fluoropyrimidine. This synergy may be attributable to the downregulation of thymidylate synthase (TS), which is frequently overexpressed in fluoropyrimidine-resistant cancer cells. However, the molecular(More)
This paper develops a new class of physics-based deformable models which can deform both globally and locally. Their global parameters are functions allowing the definition of new parameterized primitives and parameterized global deformations. These new global parameter functions improve the accuracy of shape description through the use of a few intuitive(More)
We present a new method for analyzing the 3D motion of the heart's le8 ventricle (LV) from tagged magnetic resonance imaging (MRI) data. Our technique is based on the development of a new class of volumetric physics-based deformable models whose parameters are functions and can capture the local shape variation of an object. These parameters require no(More)
The authors present a new method for analyzing the motion of the heart's left ventricle (LV) from tagged magnetic resonance imaging (MRI) data. Their technique is based on the development of a new class of physics-based deformable models whose parameters are functions. They allow the definition of new parameterized primitives and parameterized deformations(More)
N-linked glycosylation is a critical determinant of protein structure and function, regulating processes such as protein folding, stability and localization, ligand-receptor binding and intracellular signalling. TβRII [type II TGF-β (transforming growth factor β) receptor] plays a crucial role in the TGF-β signalling pathway. Although N-linked glycosylation(More)
Although people usually contact a surface with some area rather than a point, most haptic devices allow a user to interact with a virtual object at one point at a time and likewise most haptic rendering algorithms deal with such situations only. In a palpation procedure, medical doctors push and rub the organ’s surface, and are provided the sensation of(More)
The deoxyribonucleic acid (DNA) methyltransferase (DNMT) inhibitor 5-aza-2′-deoxycytidine (5-aza-dC) has been used as a drug in a part of cancer therapy. However, because of its incorporation into DNA during DNA synthesis, 5-aza-dC can cause DNA damage, mutagenesis, and cytotoxicity. In view of the adverse effects of 5-aza-dC, DNMT-targeted inhibition may(More)
BACKGROUND Deep sequencing techniques provide a remarkable opportunity for comprehensive understanding of tumorigenesis at the molecular level. As omics studies become popular, integrative approaches need to be developed to move from a simple cataloguing of mutations and changes in gene expression to dissecting the molecular nature of carcinogenesis at the(More)