Jin-ping Wang

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Acute viral myocarditis (AVMC) is characterized by virus-triggered myocardial inflammation, and Coxsackievirus B3 (CVB3) is the primary pathogen. We previously proved that Th17 cells, besides having proinflammatory effects, were involved in AVMC by enhancing humoral response. However, the relationship between Th17 cells and CVB3 replication remains unknown.(More)
Anti-adenine nucleotide translocator (ANT) autoantibodies are related to the development of Coxsackievirus B3 (CVB3)-triggered acute viral myocarditis (AVMC). Recently, studies suggested that IL-17 especially produced by a novel CD4(+) Th-cell subset Th17 cells contributed to the production of pathogenic autoantibodies in some autoimmune diseases. However,(More)
This study was aimed at studying the effect of the induction of immune tolerance to swine cardiac myosin from anti-L3T4 monoclonal antibody injection and whether the immune tolerance could protect mice with myosin-induced myocarditis from myocardial injury. Twenty-four Balb/c mice were divided into two groups at random. All of the mice were immunized with(More)
OBJECTIVE To investigate the autoimmune mechanism in dilated cardiomyopathy (DCM). METHODS Thirty-six male Balb/c mice were randomly divided into 2 groups: DCM group to be immunized with human mitochondrion ADP/ATP vector polypeptides and control group (sham immunization group) to be injected with immune fluid without the polypeptide. Before the injection(More)
BACKGROUND AND OBJECTIVES Evidence showed involvement of neural activity in acute myocardial ischaemia but the knowledge about the role in the pathology is still limited. The objective of this study was to examine whether low cervical and upper thoracic epidural anaesthesia could reduce apoptosis of the myocardium induced by 3-h and 6-h permanent coronary(More)
Nociceptin/orphanin FQ (N/OFQ) possesses modulatory effects on somatic noxious signals in spinal cord, while the potential role in visceral nociception remains elusive. We designed this study to investigate the hypothesis that cardiac nociceptive signals from acute ischemic myocardium to the spinal cord are transmitted or modulated by mechanisms including(More)
Vasorelaxant properties of N-2-(ferulamidoethyl)-nitrate (ferulate nitrate, FLNT), a newly synthesized nitrate, were compared with those of isosorbide dinitrate, nicorandil, nitroglycerin, and 8-bromoguanosine 3,5-cyclic monophosphate (8-Br-cGMP) in rat aorta pre-contracted by phenylephrine. FLNT produced vasorelaxation in a concentration-dependent manner(More)
OBJECTIVE Previous studies indicate that disturbance of respiratory functions during acute myocardial ischemia and infarction was not always parallel with decline of cardiac functions, indicating that some non-hemodynamic mechanism might be underlying the changes in the lungs. METHODS The current study was designed to investigate the changes in the(More)
To determine whether ferilnic nirate (FLNT) can precondition the rat heart against myocardial ischemia/reperfusion (I/R) damage and its mechanism, two groups of experiments were conducted. In the first group of experiments, rats were divided among four treatment groups: sham group; solvent with I/R (I/R control group); FLNT pretreatment with I/R (I/R FLNT(More)