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Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis.
TLDR
The overexpression of miR-1260b inNSCLC with LN metastasis can be regarded as a specific signature for early progression and prognosis of NSCLC. Expand
Nuclear factor-κB and apoptosis in patients with intracerebral hemorrhage
TLDR
Observations indicate that apoptosis has a major role in pathological cell death after ICH and that activation of NF-κB is positively related to the progress of apoptosis. Expand
Progranulin expression in breast cancer with different intrinsic subtypes.
TLDR
It was found that high progranulin expression was associated with higher breast carcinoma angiogenesis, reflected by increased vascular endothelial growth factor expression and higher microvessel density, and no immunohistochemical evidence currently exists to correlate progranul expression with clinicopathological features in different intrinsic subtypes of breast carcinomas biopsies. Expand
Clinicopathologic and prognostic implications of progranulin in breast carcinoma.
TLDR
Progranulin may be a valuable marker for assessing the metastasis and prognosis of breast cancer, and could provide the basis for new combination regimens with antiangiogenic activity. Expand
Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model
TLDR
It is demonstrated that MK-AS was an effective antitumor antisense oligonucleotide in vivo in mice; its antitumors effect is associated with the increase of pro-apoptotic proteins, such as p53, Bax, and caspase-3, and the decrease of the anti-ap optotic protein, Bcl-2. Expand
Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma.
TLDR
MK-AS increases the chemosensitivity in HepG2 cells and in situ human HCC model, and the combination of MK-AS and ADM has a much better in vitro and in vivo synergism. Expand
Upregulation of MiR-1280 Expression in Non-small Cell Lung Cancer Tissues
TLDR
The expression level of miR-1280 could be regarded as a biomarker for non-small cell lung cancer (NSCLC) and in 54 patients (75%), the miR -1280 expression in the NSCLC tissues was upregulated, and no case showed a downregulation ofmiR- 1280 expression. Expand
[Expression of midkine and its relationship with HBV infection in hepatocellular carcinomas].
TLDR
HCC overexpresses MK at the mRNA and protein level and the overexpression of the MK protein might be correlated with the existence of HBV DNA in the nuclei of carcinoma tissue. Expand
In vitro and in vivo suppression of hepatocellular carcinoma growth by midkine-antisense oligonucleotide-loaded nanoparticles.
TLDR
The in vitro proliferation of HepG2 cells was significantly inhibited by the nanoparticles packaged with MK-ASODNs (NANO) and the NANO-AS ODNs significantly inhibited the growth of HCC in the mouse model. Expand
Antisense oligonucleotide targeting midkine suppresses in vivo angiogenesis.
TLDR
MK-AS is an effective antiangiogenesis agent in vivo and suppressed the angiogenesis both in human hepatocellular carcinoma cell line (HEPG2)-induced CAM and in situ human HCC tissues. Expand
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