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Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis.

The overexpression of miR-1260b inNSCLC with LN metastasis can be regarded as a specific signature for early progression and prognosis of NSCLC.
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Nuclear factor-κB and apoptosis in patients with intracerebral hemorrhage

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Progranulin expression in breast cancer with different intrinsic subtypes.

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Clinicopathologic and prognostic implications of progranulin in breast carcinoma.

Progranulin may be a valuable marker for assessing the metastasis and prognosis of breast cancer, and could provide the basis for new combination regimens with antiangiogenic activity.
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Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model

It is demonstrated that MK-AS was an effective antitumor antisense oligonucleotide in vivo in mice; its antitumors effect is associated with the increase of pro-apoptotic proteins, such as p53, Bax, and caspase-3, and the decrease of the anti-ap optotic protein, Bcl-2.
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Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma.

MK-AS increases the chemosensitivity in HepG2 cells and in situ human HCC model, and the combination of MK-AS and ADM has a much better in vitro and in vivo synergism.
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Upregulation of MiR-1280 Expression in Non-small Cell Lung Cancer Tissues

The expression level of miR-1280 could be regarded as a biomarker for non-small cell lung cancer (NSCLC) and in 54 patients (75%), the miR -1280 expression in the NSCLC tissues was upregulated, and no case showed a downregulation ofmiR- 1280 expression.
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In vitro and in vivo suppression of hepatocellular carcinoma growth by midkine-antisense oligonucleotide-loaded nanoparticles.

The in vitro proliferation of HepG2 cells was significantly inhibited by the nanoparticles packaged with MK-ASODNs (NANO) and the NANO-AS ODNs significantly inhibited the growth of HCC in the mouse model.
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Antisense oligonucleotide targeting midkine suppresses in vivo angiogenesis.

MK-AS is an effective antiangiogenesis agent in vivo and suppressed the angiogenesis both in human hepatocellular carcinoma cell line (HEPG2)-induced CAM and in situ human HCC tissues.
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MiR-1260b promotes the migration and invasion in non-small cell lung cancer via targeting PTPRK.

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