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BACKGROUND The mitotic Aurora-A kinase exerts crucial functions in maintaining mitotic fidelity. As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which Aurora-A enhances cancer cell survival remain to be elucidated. RESULTS Here, we found that Aurora-A overexpression was closely… (More)
Further chemical investigation of the plant of Bruguiera gymnorrhiza led to the isolation of a new 8-hydroxyquercetagetin glycoside, namely brugymnoside A (1). The structure of the new isolate was elucidated on the basis of extensive spectroscopic analysis. Compound 1 was evaluated for its antioxidant activity by the cellular antioxidant assay method.