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A Molecular Determinant of Nickel Inhibition in Cav3.2 T-type Calcium Channels*
TLDR
Findings indicate that His-191 in the S3–S4 loop is a critical residue conferring nickel block to Cav3.3.2 and reveal a novel role for the S4 loop to control ion permeation through T-type Ca2+ channels. Expand
Ionotropic Glutamate Receptors IR64a and IR8a Form a Functional Odorant Receptor Complex In Vivo in Drosophila
TLDR
Ind immunoprecipitated the IR64a protein from lysates of fly antennal tissue and identified IR8a as a receptor subunit physically associated with IR 64a by mass spectrometry, providing direct evidence that IR8A is a subunit that forms a functional olfactory receptor with IR64A in vivo to mediate odor detection. Expand
Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation
TLDR
The discovery of an association between HDACi and the Ngn1, Math1 and p15 promoters extends the importance of HDAC inhibition as a key regulator of neuronal differentiation at the transcriptional level. Expand
A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons
The excitability of hippocampal pyramidal neurons is regulated by activation of metabotropic glutamate receptors, an effect that is mediated by modulation of R-type calcium channels.
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
TLDR
The results are the first to show that stimulation of NPCs may lead to either proliferation or neuronal differentiation, depending on the level of NMDA receptor activation, and suggest that neurogenesis in the developing brain is likely to be both directly and indirectly regulated by complex interactions between Ca2+ influx and excitation-releasable cytokines, even at mild levels of excitation. Expand
Zinc Activates TREK-2 Potassium Channel Activity
TLDR
Stimulation by Zn2+ may be used as a criterion of TREK-2, distinguishing it from other two-pore K+ channels. Expand
Activation of protein kinase C augments T‐type Ca2+ channel activity without changing channel surface density
TLDR
PMA modulation of the activities of Cav3.2 T‐type channels reconstituted in Xenopus oocytes and the underlying mechanism is compared, indicating that PMA augmented T‐ type channel currents via activation of oocyte PKC. Expand
Divalent metals differentially block cloned T-type calcium channels
TLDR
Results suggest that besides Ni2+, Cu2+ and Zn2+ can be used as selective blockers of &agr;1 H at low concentrations. Expand
Synergistic Actions of Metabotropic Acetylcholine and Glutamate Receptors on the Excitability of Hippocampal CA1 Pyramidal Neurons
TLDR
It is shown that group I metabotropic glutamate receptors and group I mGluRs synergistically increase the excitability of hippocampal CA1 pyramidal neurons by converting the post-burst afterhyperpolarization to an afterdepolarization via a rapidly reversible upregulation of Cav2.3 R-type calcium channels. Expand
Molecular identification of Ca(2+)channels in human sperm
TLDR
It is proposed that not only T-type but also non-L-type calcium channels may be major gates for the external calcium influx, required for the acrosome reaction of mammalian spermatozoa. Expand
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