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Glycosaminoglycans (GAGs) play a critical role in binding and activation of growth factors involved in cell signaling critical for developmental biology. The biosynthetic pathways for GAGs have been elucidated over the past decade and now analytical methodology makes it possible to determine GAG composition in as few as 10 million cells. A glycomics(More)
—In this paper, we study Coded relay (Crelay) in multi-hop wireless networks. Crelay exploits both partial packets and overhearing capabilities of the wireless nodes, and uses Forward Error Correction code in packet forwarding. When a node overhears a partial packet from an upstream node, it informs the upstream node about the number of parity bytes needed(More)
The identification of novel tumor-associated antigens, especially those shared among patients, is urgently needed to improve the efficacy of immunotherapy for multiple myeloma (MM). In this study, we examined whether Dickkopf-1 (DKK1), a protein that is not expressed in most normal tissues but is expressed by tumor cells from almost all patients with(More)
We have demonstrated the detection of 2.5 ␮M target DNA labeled with 16 nm Fe 3 O 4 nanoparticles ͑NPs͒ and 50 nm commercial MACS™ NPs using arrays of magnetic tunnel junction sensors with ͑001͒-oriented MgO barrier layers. Signal-to-noise ratios of 25 and 12 were obtained with Fe 3 O 4 and MACS™ NPs, respectively. These data show conclusively that(More)
Unsharp masking (USM) sharpening is a basic technique for image manipulation and editing. In recent years, the detection of USM sharpening has attracted attention from image forensics point of view. After USM sharpening, overshoot artifacts, which shape image texture, are generated along image edges. By utilizing the special characteristic of the texture(More)
The effect of nanoparticle size (30-120 nm) on magnetic resonance imaging (MRI) of hepatic lesions in vivo has been systematically examined using polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles (PVP-IOs). Such biocompatible PVP-IOs with different sizes were synthesized by a simple one-pot pyrolysis method. These PVP-IOs exhibited good(More)
MRI is one of the most important imaging tools in clinics. It interrogates nuclei of atoms in a living subject, providing detailed delineation with high spatial and temporal resolutions. To compensate the innate low sensitivity, MRI contrast probes were developed and widely used. These are typically paramagnetic or superparamagnetic materials, functioning(More)
UNLABELLED The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for PET and MRI scans of tumor integrin alphavbeta3 expression. METHODS Polyaspartic acid (PASP)-coated IO (PASP-IO) nanoparticles were synthesized using a coprecipitation method, and particle size and magnetic properties were measured. A phantom study(More)
Engineered nanoparticles with theranostic functions have attracted a lot of attention for their potential role in the dawning era of personalized medicine. Iron oxide nanoparticles (IONPs), with their advantages of being non-toxic, biodegradable and inexpensive, are candidate platforms for the buildup of theranostic nanostructures; however, progress in(More)