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The Hedgehog signaling pathway is linked to a variety of diseases, notably a range of cancers. The first generation of drug screens identified Smoothened (Smo), a membrane protein essential for signaling, as an attractive drug target. Smo localizes to the primary cilium upon pathway activation, and this transition is critical for the response to Hedgehog(More)
Hedgehog (Hh) signaling promotes tumorigenesis. The accumulation of the membrane protein Smoothened (Smo) within the primary cilium (PC) is a key event in Hh signal transduction, and many pharmacological inhibitors identified to date target Smo's actions. Smo ciliary translocation is inhibited by some pathway antagonists, while others promote ciliary(More)
The advent of GPUs with programmable shaders on mobile phones has motivated developers to utilize GPU to offload computationally intensive tasks and relive the burden of embedded CPU. In this paper, we present a set of metrics to measure characteristics of a mobile phone GPU with the focus on image processing algorithms. These measures assist users in(More)
In this paper, we analyze the key factors underlying the implementation, evaluation, and optimization of image processing and computer vision algorithms on embedded GPU using OpenGL ES 2.0 shader model. First, we present the characteristics of the embedded GPU and its inherent advantage when compared to embedded CPU. Additionally, we propose techniques to(More)
This letter proposes a novel warping-based method for the content-driven retargeting of stereoscopic images. Conventional algorithms in single image retargeting generally do not consider the scene depth saliency and disparity consistency when applied independently to left and right images . Therefore, the salient region and stereoscopic correlation of(More)
A possible role of metabolism in 1-bromopropane (1-BP)-induced hepatotoxicity was investigated in male ICR mice. The depletion of glutathione (GSH) by formation of GSH conjugates was associated with increased hepatotoxicity in 1-BP-treated mice. The formation of S-propyl and 2-hydroxypropyl GSH conjugates were identified in the liver following 1-BP(More)
A heat pump system requires proper refrigerant charge amount. Once refrigerant is charged into a heat pump system, its charge amount is fixed. For this reason, prediction of optimal refrigerant charge amount is very important in order to yield best performance. Too low charge amount degrades capacity of heat pump. On the other hand, excessive charge amount(More)
This paper proposes an affine projection algorithm (APA) using the inner product between input vectors. The existing APAs have fast convergence rate but large steady-state estimation errors. In order to reduce the estimation errors, the proposed algorithm adjusts the number of the input vectors by grouping of the input vectors. The grouping process uses the(More)
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