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—In this paper, a generic rule-base inference methodology using the evidential reasoning (RIMER) approach is proposed. Existing knowledge-base structures are first examined, and knowledge representation schemes under uncertainty are then briefly analyzed. Based on this analysis, a new knowledge representation scheme in a rule base is proposed using a belief(More)
Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as signaling molecules in intercellular communication. Here, we report the surprising finding that exogenous plant miRNAs are present in the sera(More)
It is well known that histone acetylases are important chromatin modifiers and that they play a central role in chromatin transcription. Here, we present evidence for novel roles of histone acetylases. The TIP60 histone acetylase purifies as a multimeric protein complex. Besides histone acetylase activity on chromatin, the TIP60 complex possesses ATPase,(More)
Erythroid cells undergo enucleation and the removal of organelles during terminal differentiation. Although autophagy has been suggested to mediate the elimination of organelles for erythroid maturation, the molecular mechanisms underlying this process remain undefined. Here we report a role for a Bcl-2 family member, Nix (also called Bnip3L), in the(More)
Principal component analysis (PCA) has been widely used for monitoring complex industrial processes with multiple variables and diagnosing process and sensor faults. The objective of this paper is to develop a new subspace identification algorithm that gives consistent model estimates under the errors-in-variables (EIV) situation. In this paper, we propose(More)
Vehicle positioning with an accuracy of 10 cm or less will enable lane-keeping assistance in addition to other safety benefits when an enhanced lane-level digital map is in place. With constantly evolving technology and sensors, a high-precision positioning system that fits into the automotive market can be expected within the next decade. Such a system(More)
An increasing amount of research has recently focused on representing affective states as continuous numerical values on multiple dimensions , such as the valence-arousal (VA) space. Compared to the categorical approach that represents affective states as several classes (e.g., positive and negative), the dimensional approach can provide more fine-grained(More)
How large are the bene…ts of Special Economic Zones and what are the channels of these bene…ts? To shed some light on these questions, I collect a unique dataset of Chinese municipality economic statistics from 1978 to 2007 and use it to evaluate the impact of a Special Economic Zone experiment aimed at attracting foreign direct investment. Guided by three(More)
Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses. The levels of miRNAs in serum are stable, reproducible, and consistent(More)