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This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC Neuroendovascular interventions using coil(More)
Zoledronic acid (ZOL) is one of the most potent nitrogen containing bisphosphonates (N-BP) which are used for cancer-induced skeletal disease by inhibiting osteoclast-mediated bone resorption. It acts by inhibiting the farnesyldiphosphate synthase which is one of several key enzymes in the mevalonate pathway consequently leading to osteoclast apoptosis.(More)
Lipid-based self-assembling vesicles were first described in 1961 and reported in 1964 by Dr. Alec D. Bangham (Bangham and Horne in J Mol Biol 8:660–668, 1964) at the Babraham Institute in Cambridge, UK, in which he wrote: “It is probable that at equilibrium each and every lipid bilayer forms an unbroken membrane-there being no exposed hydrocarbon/water(More)
OBJECTIVE The aim of this study was to compare the shear bond strength (SBS) of orthodontic brackets bonded to zirconia surfaces using three different zirconia primers and one silane primer, and subjected to thermocycling. METHODS We designed 10 experimental groups following the surface treatment and thermocycling. The surface was treated with one of the(More)
CD133+ cell subpopulation in U87 MG cells displays glioblastoma stem cell (GSC) like properties. Notch, a key regulator of stem cells, is also over-activated in GSCs. It was previously reported that γ-secretase inhibitors inhibit the Notch pathway by targeting the γ-secretase complex. To examine the GSCs, CD133+ cells were separated from the U87 MG cells by(More)
A new cyclooxygenase-2 inhibitor (code: PCX-3) was synthesized as a sodium salt form of celecoxib, a non-steroidal anti-inflammatory drug (NSAID), and tested for its anticancer activity using human colon adenocarcinoma cells (HT-29) in vitro. Anti-proliferative effect of HT-29 cells by PCX-3 in DPPC/Chol liposomes was more effective than the free PCX-3 by(More)
Previously, we have reported the preparation and characterization of mucoadhesive pellets of metformin hydrochloride using four high-viscosity polymers including hydroxymethylcellulose (HPMC), HPMC/carbopol, sodium carboxylmethylcellulose (Na-CMC) and sodium alginate (Na-Alg) (Piao et al., Arch Pharm Res 32:391–397, 2009). Here, pharmacokinetic and(More)
Glioblostoma (GBM) cancer stem cells (CSCs) are considered to associating with glioblastoma cancer initiation, drug (or radio) resistance and malignancy. GBM CSCs, which are identified as subpopulation of CD133 + /ALDH1 + , are known to show resistance to the most of chemotherapy and radiation therapy [1]. Angiopep-2 (An2) is targeted ligand to Low density(More)
Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs) is important because these cells are regarded as culprit of breast cancer relapse. Accomplishing this kind of strategy requires a specific drug-delivery system using the distinct features of liposomes. Studies on targeted liposomal delivery systems have indicated the(More)