Jin-Seok Choi

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The purpose of this study was to investigate the possible effects of licochalcone A (a herbal medicine) on the pharmacokinetics of nifedipine and its main metabolite, dehydronifedipine, in rats. The pharmacokinetic parameters of nifedipine and/or dehydronifedipine were determined after oral and intravenous administration of nifedipine to rats in the absence(More)
Biodegradable nanoparticles with diameters below 1000nm are of great interest in the contexts of targeted delivery and imaging. In this study, we prepared PLGA nanoparticles with well-defined sizes of ∼70nm (NP70), ∼100nm (NP100), ∼200nm (NP200), ∼400nm (NP400), ∼600nm (NP600) and ∼1000nm (NP1000) using facile fabrication methods based on a(More)
The purpose of this study was to investigate the possible effects of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, simvastatin, on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. HMG-CoA reductase inhibitors and diltiazem are sometimes prescribed as a combination therapy for the prevention or(More)
PLGA is a FDA-approved biocompatible and biodegradable polymer that is widely used in biomedical fields including drug delivery. Micro and nanoparticles based on PLGA have been extensively studied as drug delivery systems. Numerous studies proved that PLGA particulate systems are highly promising drug carriers for tumor targeting as well as pulmonary, oral,(More)
Because wireless links are subject to disturbance and failures , supporting disconnected operations is important issues in mobile computing research. Many algorithms have been proposed for supporting the efficient disconnected operations to continue performing task with a low communication cost and are focused on how the mobile client-server model can be(More)
The purpose of this study was to investigate the possible effects of pioglitazone on the pharmacokinetics of nifedipine and its main metabolite, dehydronifedipine, in rats. The effects of pioglitazone on P-glycoprotein (P-gp) and cytochrome P450 (CYP)3A4 activities were also evaluated. Nifedipine was mainly metabolized by CYP3A4. The pharmacokinetic(More)
BACKGROUND The aim of this study was to investigate the effects of nifedipine on the bioavailability and pharmacokinetics of repaglinide in rats. METHODS The effect of nifedipine on P-glycoprotein (P-gp) and cytochrome P450 (CYP) 3A4 activity was evaluated. The pharmacokinetic parameters of repaglinide and blood glucose concentrations were also determined(More)
A series of 2-amino-3-cyano-4H-chromen-4-ylphosphonates have been synthesized by reacting substituted salicylaldehydes, malononitrile, and dialkylphosphites using a catalytic amount of dibutylamine as an organocatalyst employing Knoevenagel, Pinner, and phospha-Michael reactions simultaneously in ethanol. This protocol is an environmentally friendly(More)
Recent studies have shown that cellular uptake of nanoparticles are strongly affected by the presence and physicochemical characteristics of protein on the surface of these nanoparticles. Hence, We developed surface-modified bovine serum albumin (BSA) nanoparticles (NPs) and evaluated the effect of surface modification on cellular uptake in two types of(More)
The rationale of this study was to improve the stability, cellular uptake, and evaluate the cytotoxicity of surface modified curcumin nanoparticles (CUR NP). CUR NP were surface modified with proteins (transferrin [Tf] and gelatin [GT]) by adsorption to improve their stability and targeting property. CUR NP were evaluated for stability, in vitro drug(More)