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RAID architectures have been used for more than two decades to recover data upon disk failures. Disk failure is just one of the many causes of damaged data. Data can be damaged by virus attacks, user errors, defective software/firmware, hardware faults, and site failures. The risk of these types of data damage is far greater than disk failure with today's(More)
This paper presents a design and implementation of a cyber-physical system (CPS) for neurally controlled artificial legs. The key to the new CPS system is the neural-machine interface (NMI) that uses an embedded computer to collect and interpret electromyographic (EMG) signals from a physical system that is a leg amputee. A new deciphering algorithm,(More)
— Online feedback-based rating systems are gaining popularity. Dealing with unfair ratings in such systems has been recognized as an important but difficult problem. This problem is challenging especially when the number of regular ratings is relatively small and the unfair ratings contribute to a significant portion of the overall ratings. In this paper,(More)
The RNA-dependent protein kinase (PKR) is activated by binding to double-stranded RNA (dsRNA). Activation of PKR by short-interfering RNAs (siRNAs) and stimulation of the innate immune response has been suggested to explain certain off-target effects in some RNA interference experiments. Here we show that PKR's kinase activity is stimulated in vitro 3- to(More)
— This paper presents a study of data storages for continuous data protection (CDP). After analyzing the existing data protection technologies, we propose a new disk array architecture that provides Timely Recovery to Any Point-in-time, referred to as TRAP-Array. TRAP-Array stores not only the data stripe upon a write to the array, but also the time-stamped(More)
—The quality-of-life of leg amputees can be improved dramatically by using a cyber-physical system (CPS) that controls artificial legs based on neural signals representing amputees' intended movements. The key to the CPS is the neural-machine interface (NMI) that senses electromyographic (EMG) signals to make control decisions. This paper presents a design(More)
  • Stephen M. Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Bryan Belikoff, Taylor H. Schreiber, Shalini Sethumadhavan +12 others
  • 2014
Intratumoral hypoxia and hypoxia inducible factor-1α (HIF-1-α)-dependent CD39/CD73 ectoenzymes may govern the accumulation of tumor-protecting extracellular adenosine and signaling through A2A adenosine receptors (A2AR) in tumor microenvironments (TME). Here, we explored the conceptually novel motivation to use supplemental oxygen as a treatment to inhibit(More)