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RAID architectures have been used for more than two decades to recover data upon disk failures. Disk failure is just one of the many causes of damaged data. Data can be damaged by virus attacks, user errors, defective software/firmware, hardware faults, and site failures. The risk of these types of data damage is far greater than disk failure with today's(More)
This paper presents a design and implementation of a cyber-physical system (CPS) for neurally controlled artificial legs. The key to the new CPS system is the neural-machine interface (NMI) that uses an embedded computer to collect and interpret electromyographic (EMG) signals from a physical system that is a leg amputee. A new deciphering algorithm,(More)
Many organs express the extracellular 3',5'-cAMP-adenosine pathway (conversion of extracellular 3',5'-cAMP to 5'-AMP and 5'-AMP to adenosine). Some organs release 2',3'-cAMP (isomer of 3',5'-cAMP) and convert extracellular 2',3'-cAMP to 2'- and 3'-AMP and convert these AMPs to adenosine (extracellular 2',3'-cAMP-adenosine pathway). As astrocytes and(More)
The COX-2 inhibitors Rofecoxib (Rof) and Lumiracoxib (Lum) were evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). Administration of Rof and Lum significantly reduced the incidence and severity of EAE, which was associated with the inhibition of MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell(More)
— Online feedback-based rating systems are gaining popularity. Dealing with unfair ratings in such systems has been recognized as an important but difficult problem. This problem is challenging especially when the number of regular ratings is relatively small and the unfair ratings contribute to a significant portion of the overall ratings. In this paper,(More)
The RNA-dependent protein kinase (PKR) is activated by binding to double-stranded RNA (dsRNA). Activation of PKR by short-interfering RNAs (siRNAs) and stimulation of the innate immune response has been suggested to explain certain off-target effects in some RNA interference experiments. Here we show that PKR's kinase activity is stimulated in vitro 3- to(More)
The quality of life of leg amputees can be improved dramatically by using a cyber physical system (CPS) that controls artificial legs based on neural signals representing amputees' intended movements. The key to the CPS is the neural-machine interface (NMI) that senses electromyographic (EMG) signals to make control decisions. This paper presents a design(More)
AIM The role of CYP1A in the protection of aristolochic acid (AA)I-induced nephrotoxicity has been suggested. In the present study we investigated the effects of beta-naphthoflavone (BNF), a non-carcinogen CYP1A inducer, on AAI-induced kidney injury. METHODS Mice were pretreated with 80 mg/kg BNF by daily intraperitoneal injection (ip) for 3 days followed(More)