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Reducing power consumption for server-class computers is important, since increased energy usage causes more heat dissipation, greater cooling requirements, reduced computational density, and higher operating costs. For a typical data center, storage accounts for 27% of energy consumption. Conventional server-class RAIDs cannot easily reduce power(More)
BACKGROUND Transgenic animals have become valuable tools for both research and applied purposes. The current method of gene transfer, microinjection, which is widely used in transgenic mouse production, has only had limited success in producing transgenic animals of larger or higher species. Here, we report a linker based sperm-mediated gene transfer method(More)
Text reuse is a common phenomenon in a variety of user-generated content. Along with the quick expansion of social media, reuses of local text are occurring much more frequently than ever before. The task of detecting these local reuses serves as an essential step for many applications. It has attracted extensive attention in recent years. However, semantic(More)
H19 RNA has been characterized as an oncogenic long non-coding RNA (lncRNA) in breast and colon cancer. However, the role and function of lncRNA H19 in glioma development remain unclear. In this study, we identified that H19/miR-675 signaling was critical for glioma progression. By analyzing glioma gene expression data sets, we found increased H19 in high(More)
Server-class computers cannot consume power without bound, since increased energy consumption translates into increased heat dissipation, greater cooling requirements, reduced computational density, and higher operating costs. For a typical data center, storage alone accounts for 27% of the energy consumption, making storage an important target for energy(More)
Nitric oxide (NO) is a short-lived gaseous signaling molecule. In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of(More)
Video segmentation is an important phase in video based traffic surveillance applications. The basic task of traffic video segmen-tation is to classify pixels in the current frame to road background or moving vehicles, and casting shadows should be taken into account if exists. In this paper, a modified online EM procedure is proposed to construct(More)
Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. We aimed to develop a lncRNA signature to improve prognosis prediction of colorectal cancer (CRC). Using a lncRNA-mining approach, we performed lncRNA(More)
Recent proteomic applications have demonstrated their potential for revealing the molecular mechanisms underlying neurodegeneration. The present study quantifies cerebellar protein changes in mice that are deficient in plasma membrane calcium ATPase 2 (PMCA2), an essential neuronal pump that extrudes calcium from cells and is abundantly expressed in(More)
Mutations of p53 cause not only loss of wild-type function but also gain of novel oncogenic functions (GOF). Accumulating evidence suggest that p53 hotspot mutations may confer different types and magnitudes of GOF. Here we add support to the heterogeneity of mutant p53 GOF by showing their unequal association with early tumor onset and spectrum of tumor(More)