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Silymarin, a mixture of bioactive flavonolignans from the milk thistle (Silybum marianum), is traditionally used in herbal medicine to defend against various hepatotoxic agents. The aim of the present study was to evaluate the protective effect of silymarin against carbon tetrachloride (CCl4)-induced liver injury in fish. Common carp, with an average(More)
The present study was to investigate the protective effect and possible mechanism of phyllanthin against carbon tetrachloride (CCl4)-induced hepatocyte damage in carp. Phyllanthin (5, 10, and 15 μg/ml) was added to carp primary hepatocytes before (pre-treatment) and after (post-treatment) incubation of the hepatocytes in medium containing CCl4 at 8 mM;(More)
The aim of the present study was to investigate the protective effects and possible mechanism of phyllanthin against carbon tetrachloride (CCl4)-induced hepatic damage in common carp. Fish were fed diet containing four doses of phyllanthin (0, 100, 300, and 600 mg/kg diet) for 60 days, and then given an intraperitoneal injection of CCl4 (30 % in arachis(More)
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