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Bone development is dynamically regulated by homeostasis, in which a balance between adipocytes and osteoblasts is maintained. Disruption of this differentiation balance leads to various bone-related metabolic diseases, including osteoporosis. In the present study, a primate-specific microRNA (miR-637) was found to be involved in the differentiation of(More)
The presence of different artifacts has long been a problem for the analysis and interpretation of electroencephalographic (EEG) recordings. Independent Component Analysis (ICA) is a technique for Blind Source Separation (BSS) and has been used to remove biomedical artifacts. In order to subtract the power line noise effectively and robustly, we use two(More)
Epigallocatechin gallate (EGCG) is a major polyphenol in green tea that has been shown to have anti-inflammatory, anti-cancer, anti-steatotic effects on the liver. Autophagy also mediates similar effects; however, it is not currently known whether EGCG can regulate hepatic autophagy. Here, we show that EGCG increases hepatic autophagy by promoting the(More)
Viruses have evolved strategies to protect infected cells from apoptotic clearance. We present evidence that HIV-1 possesses a mechanism to protect infected macrophages from the apoptotic effects of the death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). In HIV-1-infected macrophages, the viral envelope protein induced macrophage(More)
BACKGROUND Maintenance chemotherapy is widely provided to patients with small cell lung cancer (SCLC). However, the benefits of maintenance chemotherapy compared with observation are a subject of debate. METHODOLOGY AND PRINCIPAL FINDINGS To identify relevant literature, we systematically searched the Medline, Embase, and Cochrane Central Register of(More)
This paper investigates adaptive pinning synchronization of a general weighted neural network with coupling delay. Unlike recent works on pinning synchronization which proposed the possibility that synchronization can be reached by controlling only a small fraction of neurons, this paper aims to answer the following question: Which neurons should be(More)
This article examines the relationship between cultural affiliation and deaf adults' motivations for genetic testing for deafness in the first prospective, longitudinal study to examine the impact of genetic counseling and genetic testing on deaf adults and the deaf community. Participants (n = 256), classified as affiliating with hearing, Deaf, or both(More)
As a recently proposed machine learning method, active learning of Gaussian processes can effectively use a small number of labeled examples to train a classifier, which in turn is used to select the most informative examples from unlabeled data for manual labeling. However, in the process of example selection, active learning usually need consider all the(More)
Reciprocal relationship usually exists between osteoblastogenesis and adipogenesis, with factors stimulating one of these processes at the same time inhibiting the other. In the present study, miR-30e was found to be involved in the reciprocal regulation of osteoblast and adipocyte differentiation. Our data indicated that miR-30e was induced in primarily(More)
BACKGROUND The regulation of protein phosphorylation requires a balance in the activity of protein kinases and protein phosphatases. Our previous data indicates that Src can increase ERK activity through Raf kinase in response to ischemic stimuli. This study examined the molecular mechanisms by which Src activates ERK cascade through protein phosphatases(More)