Jin Huh

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A key obstacle to creating sophisticated genetic circuits has been the lack of scalable device libraries. Here we present a modular transcriptional repression architecture based on clustered regularly interspaced palindromic repeats (CRISPR) system and examine approaches for regulated expression of guide RNAs in human cells. Subsequently we demonstrate that(More)
BACKGROUND Laparoscopic cholecystectomy (LC) has traditionally been performed under general anesthesia, however, owing in part to the advancement of surgical and anesthetic techniques, many laparoscopic cholecystectomies have been successfully performed under the spinal anesthetic technique. We hoped to determine the feasibility of segmental epidural(More)
BACKGROUND The presence of a transitional vertebra can create difficulty in identifying the lumbar level corresponding to an exiting nerve root at the time of a spinal nerve block. We investigated the possibility that the muscle innervation pattern and sensory dermatomes of the lumbar nerve roots are altered when a lumbosacral transitional vertebra is(More)
provided the original work is properly cited. CC POEMS syndrome is a rare multisystemic disorder. It is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes [1]. Because it is also associated with pulmonary dysfunction, a patient with POEMS syndrome may have postoperative respiratory difficulty. In this(More)
BACKGROUND The purpose of this study was to evaluate the gender-related changes in the function and distribution of α(1)-adrenoceptors in the distal mesenteric artery of streptozotocin (STZ)-induced diabetic rats at the level of α(1)-adrenoceptor subtypes. METHODS Diabetes was induced by intravenous injection of STZ in a dose of 60 mg/kg through the tail(More)
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