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For clustered count data with excess zeros where the observations are either over-dispersed or under-dispersed, the zero-inflated generalized Poisson mixed (ZIGPM) regression model may be appropriate, in which the baseline discrete distribution is a generalized Poisson distribution, which is a natural extension of standard Poisson distribution. Motivated by(More)
The objective of the present study is to find out the quantitative relationship between progression of liver fibrosis and the levels of certain serum markers using mathematic model. We provide the sparse logistic regression by using smoothly clipped absolute deviation (SCAD) penalized function to diagnose the liver fibrosis in rats. Not only does it give a(More)
This work develops diagnostics for skew-t-normal nonlinear models which provides an useful extension for ordinary normal regression models when the data set under consideration involves heavy tail and asymmetric outcomes. The case-deletion model (CDM) is considered, and several diagnostic measures are derived and discussed. Furthermore, we discuss score(More)
To obtain efficient estimation of parameters is a major objective in population pharmacokinetic study. In this paper, we propose an empirical likelihood-based method to analyze the population pharmacokinetic data based on the generalized linear model. A nonparametric version of the Wilk’s theorem for the limiting distributions of the empirical likelihood(More)