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The effects of external protons on single sodium channel currents recorded from cell-attached patches on guinea pig ventricular myocytes were investigated. Extracellular protons reduce single channel current amplitude in a dose-dependent manner, consistent with a simple rapid channel block model where protons bind to a site within the channel with an(More)
Innervation of nerve and muscle cells during development is often accompanied by changes in the expression and function of ion channels in the postsynaptic cell. However, the signaling pathways whereby the presynaptic nerve influences the properties of the postsynaptic cell are less well understood. Indirect evidence suggests that cardiac voltage-gated Na+(More)
gamma-Aminobutyric acid (GABA) and glutamate (Glu) are considered as the predominant inhibitory and excitatory neurotransmitters in mammalian central nervous systems (CNS), respectively. The presence of the GABA system and metabotropic glutamate receptors in sperm prompted us to explore the existence of ionotropic glutamate receptors and glutamate(More)
Human chorionic somatomammotropin (CS) synthesis results from the independent expression of two homologous genes, CS-A and CS-B. A transcription enhancer factor-1 (TEF-1) element and an upstream 81 bp modulatory domain, containing repressor (RF-1) and derepressor (DF-1) activities, are important for efficient CS-B enhancer function in transfected placental(More)
It is well documented that g-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosome reaction induced by GABA and progesterone. GABA transporter I (GAT1) also existed in testis and sperm, but its physiological function was(More)
Early maturity is a particularly important agronomic trait for cotton breeding in China and is determined by many morphological and phenological traits. The time of floral initiation is one of most important factors related to early maturation of cotton. The aim of this study was to identify differentially expressed (DE) genes related to floral initiation(More)
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