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Identified as a strategic area, supply chain transformation plays a critical role in today's IBM business. In this paper, we introduce an effort in IBM Research Division named SmartSCOR, which provides a comprehensive framework and methodology for On-Demand SCM problem-solving based on the cross-industry process standard Supply Chain Operations Reference(More)
PURPOSE Glial cells are structurally and functionally linked to neuronal tissues. Pathologically, the cells may be activated and characterized by increased size and number and altered cellular properties. In glaucoma, pathologic mechanisms within the anterior optic nerve may include glial activation. This study examines morphologic changes of glial cells in(More)
PURPOSE To characterize retinal functional consequences of elevated intraocular pressure (IOP) in a rat model of experimental glaucoma. METHODS Unilateral elevation of IOP was produced by hypertonic saline injection into an episcleral vein in 20 adult male Brown-Norway rats. IOP was measured in both eyes of awake animals four to five times per week. After(More)
Business process is crucial to the success of any business. Business process modeling enables a common understanding and analysis of a business process, and simulation is an effective way to diagnose and evaluate complex business processes. There are lots of software tools in market for business process modeling and simulation, however, a common issue for(More)
PURPOSE To describe varicosities of intraretinal ganglion cell axons in the nerve fiber layer of human and nonhuman primate retinas. METHODS Intraretinal ganglion cell axons of seven human donors (1-85 years old) and two nonhuman primates (Macaca mulatta, 15 and 17 years old) were immunohistochemically stained with an antibody of neurofilament on(More)
IBM General Business Simulation Environment (GBSE) is a supply chain simulation tool developed by IBM China Research Lab. It can capture supply chain dynamics with finest level of granularity and provides great insights to a supply chain's real operations. GBSE is designed for tactical level decision making; it is proper for supply chain what-if analysis(More)
Acid-sensing ion channels, or ASICs, are members of the amiloride-sensitive cationic channel superfamily that are predicted to have intracellular amino and carboxyl termini and two transmembrane domains connected by a large extracellular loop. This prediction comes from biochemical studies of the mammalian epithelial sodium channels where glycosylation(More)
Explicit model reduction for nonlinear systems with no prior information about the type of nonlinearity involved is difficult and challenging. It is easier to reduce nonlinear systems which nonlinearity is known. In this paper we introduce two nonlinear model reduction techniques for quadratic nonlinear systems. The first technique is nonlinear balanced(More)