Jin Chang

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Folate-PEG coated cationic modified chitosan--cholesterol liposomes for tumor-targeted drug delivery.

Hanjie Wang, Peiqi Zhao, +4 authors Jin Chang
Biomaterials
2010

In this paper, a folate-PEG coated polymeric liposome (FPL) formed from octadecyl-quaternized lysine modified chitosan (OQLCS) and cholesterol has been prepared successfully. The OQLCS and its… (More)

A novel method to enhance quantum yield of silica-coated quantum dots for biodetection.

Bingbo Zhang, Xiaoqun Gong, Lijuan Hao, Jing Cheng, Yan Han, Jin Chang
Nanotechnology
2008

In this paper, based on selecting the appropriate type of quantum dots (QDs), a novel method is developed to enhance the quantum yield (QY) of silica-coated QD nanoparticles (SQDNPs). The effect of… (More)

PLGA/polymeric liposome for targeted drug and gene co-delivery.

Hanjie Wang, Peiqi Zhao, +4 authors Jin Chang
Biomaterials
2010

Chemotherapy is one of the most effective approaches to treat cancers in the clinic, but the problems, such as multidrug resistance (MDR), low bioavailability and toxicity, severely constrain the… (More)

PEGlated magnetic polymeric liposome anchored with TAT for delivery of drugs across the blood-spinal cord barrier.

Hanjie Wang, Shuangnan Zhang, +5 authors Jin Chang
Biomaterials
2010

Due to the existence of the blood-spinal cord barrier (BSCB), many therapeutic macromolecular agents, such as drugs, protein and gene, cannot pass through this barrier to reach the site of injury,… (More)

Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging

Weisheng Guo, Na Chen, +4 authors Jin Chang
Theranostics
2013

A facile strategy is reported here for synthesis of Zn-Cu-In-S/ZnS (ZCIS/ZnS) core/shell QDs to address the synthetic issues that the unexpected blue-shift of CuInS(2)-based nanocrystals. In this… (More)

Intrinsically Radioactive [64Cu]CuInS/ZnS Quantum Dots for PET and Optical Imaging: Improved Radiochemical Stability and Controllable Cerenkov Luminescence

Weisheng Guo, Xiaolian Sun, +7 authors Xiaoyuan (Shawn) Chen
ACS nano
2015

Functionalized quantum dots (QDs) have been widely explored for multimodality bioimaging and proven to be versatile agents. Attaching positron-emitting radioisotopes onto QDs not only endows their… (More)

Characterization of novel multifunctional cationic polymeric liposomes formed from octadecyl quaternized carboxymethyl chitosan/cholesterol and drug encapsulation.

Xiao F Liang, Han Jia Wang, +5 authors Jin Chang
Langmuir : the ACS journal of surfaces and…
2008

The design and construction of effective delivery vectors for drugs is very important. We have discovered that octadecyl quaternized carboxymethyl chitosan (OQCMC) in combination with cholesterol… (More)

GM130 Is Required for Compartmental Organization of Dendritic Golgi Outposts

Wei Zhou, Jin Chang, +4 authors Bing Ye
Current Biology
2014

Golgi complexes (Golgi) play important roles in the development and function of neurons [1-3]. Not only are Golgi present in the neuronal soma (somal Golgi), they also exist in the dendrites as Golgi… (More)

Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo.

Lei Han, Anling Zhang, +4 authors Jin Chang
Human gene therapy
2010

Polyamidoamine (PAMAM) dendrimer and Tat peptides were conjugated to bacterial magnetic nanoparticles (BMPs) for the construction of an efficient and targeted gene delivery system with transmembrane… (More)

Magnetic paclitaxel nanoparticles inhibit glioma growth and improve the survival of rats bearing glioma xenografts.

Mingming Zhao, Chao Liang, +5 authors Junli Tai
Anticancer research
2010

UNLABELLED Paclitaxel has fared poorly in clinical trials against brain glioma. We hypothesized that superparamagnetic nanocarriers may enhance its bioactivities by delivering it into the brain. … (More)

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