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In the chick embryo (20 h incubation, gastrula stage), the apical membrane of the ectodermal cells shows a high density of a non-selective cation channel which is blocked by very low extracellular Ca2+ concentrations. Properties of this channel were studied at the single-channel level using the patch-clamp technique in the cell-attached mode. With 1 mmol/l(More)
Some epithelial nonselective cation channels although in an open conformation are impermeable because they are blocked by extracellular Ca2+ ions. Such a channel is present in the apical membrane of the ectodermal cells of the chick gastrula. This single-channel study shows that protonation of a site located inside the pore of this embryonic channel reduces(More)
T he feasibility of using field experiments to optimize marketing decisions remains relatively unstudied. We investigate category pricing decisions that require estimating a large matrix of cross-product demand elas-ticities and ask the following question: How many experiments are required as the number of products in the category grows? Our main result(More)
In recent years, many firms have had greater opportunities to conduct field experiments to help improve their marketing decisions, but the practical value of using field experiments to optimize marketing decisions remains relatively unstudied. We investigate advertising and promotion decisions that require estimating a large matrix of cross-product demand(More)
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