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Seven new cassane furanoditerpenes from the seeds of Caesalpinia minax.
TLDR
Compound 1 is the first example of an A-seco-rearranged cassane furanoditerpene with an unusual skeleton isolated from the genus Caesalpinia, and all compound inhibitory effects on influenza virus neuraminidase (NA) in vitro were valued for the first time.
In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists
TLDR
In silico analysis and experimental validation together demonstrated that lignan extracts from KL can target 5-HT1AR in insomniac rats, which could shed light on its use as a potential 5- HT1AR agonist drug.
Two new isoxazolines from the husks of Xanthoceras sorbifolia Bunge
TLDR
The structures with isoxazoline skeletons were found to show potential anti-asthmatic (AM) and anti-anaphylaxis (AP) activities and compounds 1 and 2 were predicted to possess high affinities for many enzymes involved in AM and AP according to the RCSB Protein Data Bank.
Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway
TLDR
MHT could mitigate the pathological changes of acute asthma-like syndrome through inhibition of the TLR9 pathway and may provide a reference for the development of a novel therapy for patients with allergic asthma.
In silico identification and experimental validation of diuresis compounds from Euphorbia lathyris for potential UT-B inhibitors
Abstract Euphorbia lathyris ( E. lathyris ), a traditional Chinese medicine, rich in diterpenoids, has been widely used for the treatment of hydropsy, especially the ascites in China, with its
Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats.
TLDR
It is found that RCI-derived ecdysterones should bind to glutamatergic NMDA-type receptors (NMDARs); specifically, in vivo modeling showed binding to the GRIN2B subunit of N MDARs, which was found also to be a node of convergence in several neurodegenerative disease pathways.
Three new sesquiterpenes from Pterocarpus santalinus
TLDR
Three new sesquiterpenes of canusesnol K, L and 12, 15-dihydroxycurcumene, along with five known ones, were isolated from the heartwood extract of Pterocarpus santalinus, and their structures were established by extensive analyses of 1D and 2D NMR spectroscopy.