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The study of genetic variants alone is not enough to explain a complex disease like cancer. Alterations in DNA methylation patterns have been associated with different types of tumor. In order to detect markers of susceptibility for the development of cutaneous melanoma and breast cancer in the Uruguayan population, we integrated genetic and epigenetic(More)
Asian-American (AA) HPV-16 variants are associated with higher risk of cancer. Abnormal activation of intracellular signaling play a critical role in cancer development and progression. Our aim was to elucidate mechanisms underlying the higher oncogenic potential attributed to AA variant. We evaluated activation of MAPK and PI3K/AKT pathways in primary(More)
  • J Hochmann
  • 1992
In accord with new findings, the gasoline is no more believed to be free of cancerogenic risk. Renal tumours in male rats and those of liver in murine females had been described also after inhalatory exposure to unleaded gasoline. A reliable epidemiological study in occupationally gasoline exposed humans is still not available (higher rate of tumours in(More)
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